Research
Original Peer-Reviewed Papers
HIV disrupts the lung molecular clock, leading to lung inflammation and features of emphysema.
Panda K, Peng JY, Santiago MJ, Rahman MS, Shaikh SB, Kaur G, Faizan MI, Islam KU, Wang T, Black SM, Evans CM, Rahman I, Chinnapaiyan S, Unwalla HJ.Commun Biol. 2026 Jan 5;9(1):11. doi: 10.1038/s42003-025-09284-1.PMID: 41486302 Free PMC article.
Li D, Liu P, Rahman I, Zand M, Pryhuber G, Dye T, Goniewicz M, Gurkar AU, Königshoff M, Eickelberg O, Mora A, Rojas M, Ma Q, Lugo-Martinez J, Bar-Joseph Z, Lanna S, Finkel T, Xie Z.Cell Rep Methods. 2026 Jan 22:101264. doi: 10.1016/j.crmeth.2025.101264. Online ahead of print.PMID: 41576958 Free article.
Advancing biological understanding of cellular senescence with computational multiomics.
Li S, Agudelo Garcia PA, Aliferis C, Becich MJ, Calyeca J, Cosgrove BD, Elisseeff J, Farzad N, Fertig EJ, Glass C, Gu L, Hu Q, Ji Z, Königshoff M, LeBrasseur NK, Li D, Ma A, Ma Q, Menon V, Mitchell JT, Mora AL, Nagaraj S, Nelson AC, Niedernhofer LJ, Rojas M, Taha HB, Wang J, Wang S, Wu PH, Xie J, Xu M, Yu M, Zhang X, Zhao Y, Adams PD, Aguayo-Mazzucato C, Baker DJ, Benz C, Bernlohr DA, Bueno M, Chen J, Childs BG, Chuang JH, Chung D, Dileepan M, Ding L, Dong M, Duncan F, Enninful A, Flynn WF, Franco AC, Furman D, Garovic V, Halene S, Herman AB, Hertzel AV, Iwasaki K, Jeon H, Kang JW, Karmakar S, Kirkland JL, Korstanje R, Kummerfeld E, Lee JH, Liu Y, Lu Y, Lugo-Martinez J, Martini H, Melov S, Musi N, Passos JF, Peters ST, Rahman I, Ramasamy R, Rindone AN, Robbins PD, Robson P, Rodriguez-Lopez J, Rosas L, Rosenthal N, Schafer MJ, Schilling B, Schmidt EL, Schneider K, Sengupta K, Shu J, So PTC, Sun L, Tchkonia T, Teneche MG, Vanegas N, Wang J, Xie J, Yin S, Zhang K, Zhu Q, Fan R; SenNet Consortium.Nat Genet. 2025 Oct;57(10):2381-2394. doi: 10.1038/s41588-025-02314-y. Epub 2025 Sep 15.PMID: 40954249 Review.
Akhtar A, Shakir M, Ansari MS, Divya, Faizan MI, Chauhan V, Singh A, Alam R, Azmi I, Sharma S, Pracha M, Uddin IM, Bashir U, Shahni SN, Chaudhuri R, Albogami S, Ganguly R, Sagar S, Singh VP, Kharya G, Srivastava AK, Mabalirajan U, Roy SS, Rahman I, Ahmad T.Cell Rep Med. 2025 Mar 18;6(3):102021. doi: 10.1016/j.xcrm.2025.102021.PMID: 40107240 Free PMC article.
Li D, Xie Z, Shaikh SB, Rahman I.Sci Rep. 2025 Jan 21;15(1):2714. doi: 10.1038/s41598-025-85373-9.PMID: 39837838 Free PMC article.
Effah F, Sun Y, Friedman A, Rahman I.Toxicol Lett. 2025 Mar;405:9-15. doi: 10.1016/j.toxlet.2025.01.007. Epub 2025 Feb 1.PMID: 39894318
Quinones Tavarez Z, Ossip DJ, Li D, Croft DP, Rahman I, Wojtovich AP.MicroPubl Biol. 2025 Aug 11;2025:10.17912/micropub.biology.001699. doi: 10.17912/micropub.biology.001699. eCollection 2025.PMID: 40873937 Free PMC
In Vitro assessments of ENDS toxicity in the respiratory tract: Are we there yet?
Muthumalage T, Sarles E, Wang Q, Hensel E, Hill T 3rd, Rahman I, Robinson R, Stroup AM, Thongphanh K, Miller LA.NAM J. 2025;1:100016. doi: 10.1016/j.namjnl.2025.100016. Epub 2025 Apr 3.PMID: 40264558 Free PMC article.
Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice.
Faizan MI, Kaur G, Shaikh SB, Effah F, Unwalla H, Rahman I.Physiol Rep. 2025 Jan;13(2):e70199. doi: 10.14814/phy2.70199.PMID: 39844449 Free PMC article.
Sun Y, Kaur G, Effah F, Friedman A, Rahman I.Toxicol Rep. 2025 Nov 21;15:102171. doi: 10.1016/j.toxrep.2025.102171. eCollection 2025 Dec.PMID: 41377029 Free PMC article.
Muthumalage T, Rahman I.Inhal Toxicol. 2025 Aug-Sep;37(7-8):369-381. doi: 10.1080/08958378.2025.2577236. Epub 2025 Nov 12.PMID: 41229158
Akhtar A, Shakir M, Ansari MS, Divya, Faizan MI, Chauhan V, Singh A, Alam R, Azmi I, Sharma S, Pracha M, Uddin IM, Bashir U, Shahni SN, Chaudhuri R, Albogami S, Ganguly R, Sagar S, Singh VP, Kharya G, Srivastava AK, Mabalirajan U, Roy SS, Rahman I, Ahmad Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity.Cell Rep Med. 2025 Mar 18;6(3):102021. doi: 10.1016/j.xcrm.2025.102021.PMID: 40107240
Li D, Xie Z, Shaikh SB, Rahman I.Altered expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users. Sci Rep. 2025 Jan 21;15(1):2714. doi: 10.1038/s41598-025-85373-9.PMID: 39837838
Quinones Tavarez Z, Ossip DJ, Li D, Croft DP, Rahman I, Wojtovich AP.Microbiota-Influenced Toxicological Responses in Caenorhabditis elegans Exposed to Strawberry and Menthol E-Liquids. MicroPubl Biol. 2025 Aug 11;2025:10.17912/micropub.biology.001699. doi: 10.17912/micropub.biology.001699. eCollection 2025.PMID: 40873937
Faizan MI, Kaur G, Shaikh SB, Effah F, Unwalla H, Rahman I.Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice. Physiol Rep. 2025 Jan;13(2):e70199. doi: 10.14814/phy2.70199.PMID: 39844449
Effah F, Sun Y, Friedman A, Rahman I. Emerging nicotine analog 6-methyl nicotine increases reactive oxygen species in aerosols and cytotoxicity in human bronchial epithelial cells. Toxicol Lett. 2025 Mar;405:9-15. doi: 10.1016/j.toxlet.2025.01.007. Epub 2025 Feb 1.PMID: 39894318
Santiago MJ, Chinnapaiyan S, Panda K, Rahman MS, Ghorai S, Rahman I, Black SM, Liu Y, Unwalla HJ. Altered Host microRNAomics in HIV Infections: Therapeutic Potentials and Limitations. Int J Mol Sci. 2024 Aug 13;25(16):8809. doi: 10.3390/ijms25168809. PMID: 39201495; PMCID: PMC11354509.
Orfin RH, Ramos Santiago JW, Decena Soriano R, Romero Acosta E, Bermudez D, Rodriguez YL, Li D, Rahman I, McIntosh S, Ossip DJ, Cupertino AP, Cartujano-Barrera F. Kick Vaping: Feasibility, acceptability, and preliminary impact of a vaping cessation text messaging intervention for Latino young adults. J Ethn Subst Abuse. 2024 Aug 28:1-13. doi: 10.1080/15332640.2024.2397422. Epub ahead of print. PMID: 39196764.
Kaur G, Wang Q, Tjitropranoto A, Unwalla H, Rahman I. Cold ischemia time alters cell-type specific senescence leading to loss of cellular integrity in mouse lungs. Exp Lung Res. 2024;50(1):184-198. doi: 10.1080/01902148.2024.2414974. Epub 2024 Oct 20. PMID: 39427288; PMCID: PMC11513191.
Nguyen ND, Rosas L, Khaliullin T, Jiang P, Hasanaj E, Ovando-Ricardez JA, Bueno M, Rahman I, Pryhuber GS, Li D, Ma Q, Finkel T, Königshoff M, Eickelberg O, Rojas M, Mora AL, Lugo-Martinez J, Bar-Joseph Z. scDOT: optimal transport for mapping senescent cells in spatial transcriptomics. Genome Biol. 2024 Nov 8;25(1):288. doi: 10.1186/s13059-024-03426-0. PMID: 39516853; PMCID: PMC11546560.
Wang Q, Goracci C, Sundar IK, Rahman I. Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis. J Inflamm (Lond). 2024 Mar 20;21(1):9. doi: 10.1186/s12950-024-00377-y. PMID: 38509574; PMCID: PMC10956237.
Wang Q, Lucas JH, Pang C, Zhao R, Rahman I. Tobacco and menthol flavored nicotine-free electronic cigarettes induced inflammation and dysregulated repair in lung fibroblast and epithelium. Respir Res. 2024 Jan 10;25(1):23. doi: 10.1186/s12931-023-02537-9. PMID: 38200492; PMCID: PMC10777495.
Orfin RH, Uceda V, Gardner C, Estrada B, Tamayo E, Hernández-Torres R, Li D, Rahman I, McIntosh S, Ossip DJ, Cupertino AP, Cartujano-Barrera F. Recruiting Latino young adults into a vaping cessation study via social media: Feasibility and cost analysis. Tob Prev Cessat. 2024 Apr 9;10. doi: 10.18332/tpc/186146. PMID: 38596182; PMCID: PMC11002960.
Orfin RH, Siddalingaiah S, Dontu V, Estrada B, Martinez C, Guerra D, Carrillo H, Cervantes-Díaz MJ, Rodríguez-Rojas DV, Rahman I, McIntosh S, Ossip DJ, Cupertino AP, Cartujano-Barrera F. Development of a Vaping Cessation Text Messaging Intervention for Latino Young Adults: A Participatory Research Approach. Community Health Equity Res Policy. 2024 Jan 5:2752535X231225928. doi: 10.1177/2752535X231225928. Epub ahead of print. PMID: 38183157.
Lucas JH, Wang Q, Meehan-Atrash J, Pang C, Rahman I. Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice. Toxicol Sci. 2024 Sep 1;201(1):48-60. doi: 10.1093/toxsci/kfae073. PMID: 38830033; PMCID: PMC11347778.
Lucas JH, Wang Q, Pang C, Rahman I. Developmental perfluorooctane sulfonic acid exposure exacerbates house dust mite induced allergic responses in adult mice. Sci Total Environ. 2024 Oct 10;946:173768. doi: 10.1016/j.scitotenv.2024.173768. Epub 2024 Jun 5. PMID: 38844226; PMCID: PMC11260234.
Quinones Tavarez Z, Croft DP, Li D, Gill SR, Wojtovich AP, Rahman I, Ossip DJ. Fruit flavors in electronic cigarettes (ECIGs) are associated with nocturnal dry cough: A population longitudinal analysis. PLoS One. 2024 Jun 28;19(6):e0306467. doi: 10.1371/journal.pone.0306467. PMID: 38941336; PMCID: PMC11213341.
Santiago MJ, Chinnapaiyan S, Panda K, Rahman MS, Ghorai S, Lucas JH, Black SM, Rahman I, Unwalla HJ. MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation. J Inflamm (Lond). 2024 Aug 27;21(1):31. doi: 10.1186/s12950-024-00405-x. PMID: 39192275; PMCID: PMC11348649.
Qixin Wang, Isaac Kirubakaran Sundar, Joseph H. Lucas, Jun-Gyu Park, Aitor Nogales, Luis Martinez-Sobrido, Irfan Rahman.Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization Nature Comm 2023
Qixin Wang, Cortney Pang, Joseph Lucas, Zhao, Irfan Rahman. Tobacco and menthol flavored nicotine-free electronic cigarettes induced inflammation and dysregulated repair in lung fibroblast and epithelium. Respiratory Research, 2023
Muthumalage T, Goracci C, Rahman I. Club cell-specific telomere protection protein 1 (TPP1) protects against tobacco smoke-induced lung inflammation, xenobiotic metabolic dysregulation, and injurious responses. FASEB Bioadv. 2024 Jan 15;6(2):53-71. doi: 10.1096/fba.2023-00115. PMID: 38344410; PMCID: PMC10853660.Gagandeep Kaur, Thivanka Muthumalage and Irfan Rahman. Clearance of senescent cells reverts the cigarette smoke-induced lung senescence and airspace enlargement in p16-3MR mice. Aging Cell, 2023
S, Boelig RC, Aghai ZH. SARS-CoV-2 Covid-19 Infection During Pregnancy and Differential DNA Methylation in Human Cord Blood Cells From Term Neonates. Epigenet Insights. 2023 Jun 30;16:25168657231184665. doi: 10.1177/25168657231184665. PMID: 37425024; PMCID: PMC10328022.
Qixin Wang, Chiara Goracci, Isaac Kirubakaran Sundar, Irfan Rahman. Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression and premature senescence during pulmonary fibrogenesis.FASEB J Bioadv, 2023
Zihe Zheng, Zidian Xie, Maciej Goniewicz, Irfan Rahman, Dongmei Li “Potential Impact of the COVID-19 Pandemic on Public Perception of Waterpipe on Reddit: Observational Study”
JMIR / JMIR, 2023
Thomas Lamb, and Irfan Rahman, PhD. Pro-inflammatory effects of aerosols from e-cigarette-derived flavoring chemicals on murine macrophages. Tox Reports 2023
Lucas, Joseph H.; Wang, Qixin; Rahman, Irfan. Perfluorooctane sulfonic acid disrupts protective tight junction proteins via protein kinase D in airway epithelial cells. Tox Sciences, 2022
Arbat, S.; Arbat, A.; Agrawal, B.; Deshpande, P.; Rahman, I.; Bakamwar, S.; Borkar, P. Environmental Exposures and Phenotype of Non-smoking COPD . Preprints 2022, 2022060334 (doi: 10.20944/preprints202206.0334.v1).. Environmental Exposures and Phenotype of Non-smoking COPD . Preprints 2022, 2022060334 (doi: 10.20944/preprints202206.0334.v1). Annals of critical care and medicine. August 2022
Thomas Lamb, Thivanka Muthumalage, Jiries Meehan-Atrash, Irfan Rahman. Nose-only Exposure to Cherry and Tobacco Flavored E-cigarettes Induced Lung Inflammation in Mice in a Sex-dependent Manner. bioRxiv 2022.06.20.496875; doi: https://doi.org/10.1101/2022.06.20.496875
Marko Manevski, Dinesh Devadoss, Shaiesh Yogeswaran, Irfan Rahman, Hitendra S. Chand
E-Cigarette Synthetic Cooling Agent WS-23 and Nicotine Aerosols Differentially Modulate Airway Epithelial Cell Responses. bioRxiv 2022.06.20.496868; doi: https://doi.org/10.1101/2022.06.20.496868
Shaiesh Yogeswaran, Marko Manevski, Hitendra S. Chand, Irfan Rahman. Synthetic Coolant WS-23 increases E-Cigarette Generated Aerosolized Acellular Reactive Oxygen Species (ROS) Levels bioRxiv 2022.06.20.496866; doi: https://doi.org/10.1101/2022.06.20.496866
Dongmei Li, Martin Zand, Timothy Dye, Maciej Goniewicz, Irfan Rahman, Zidian Xie
An evaluation of RNA-seq differential analysis methods bioRxiv 2022.02.09.479723; doi: https://doi.org/10.1101/2022.02.09.479723
Sadiya Shaikh, Wai Cheung Tung, Joseph Lucas, Shaiesh Yogeswaran, Dongmei Li, and Irfan Rahman. Flavor Classification/Categorization and Differential Toxicity of Oral Nicotine Pouches (ONPs) in Lung Epithelial Cells. BioRxiv 10.1101/2022.07.06.498919: doi: https://doi.org/10.1101/2022.07.06.498919, 2022, published Int J Env Health Res 2022.
Yogeswaran S, Rahman I. Differences in Acellular Reactive Oxygen Species (ROS) Generation by E-Cigarettes Containing Synthetic Nicotine and Tobacco-Derived Nicotine.
Toxics. 2022 Mar 11;10(3):134. doi: 10.3390/toxics10030134.PMID: 35324759
Marko Manevski, Dinesh Devadoss, Christopher Long, Shashi P. Singh, Mohd Wasim Nasser, Glen M Borchert, Madhavan N Nair, Irfan Rahman, Mohan Sopori, Hitendra S Chand. Increased Expression of LASI LncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia. Frontiers in Immunology, section Mucosal Immunity. In press, 2022
McGraw MD, Croft DP, Nacca NE, Rahman I Reduced plasma phosphatidylethanolamines in e-cigarette, or vaping, product use-associated lung injury (EVALI). .Pediatr Pulmonol. 2022 Feb 28. doi: 10.1002/ppul.25874. Online ahead of print.PMID: 35233972
Wang Q, Unwalla H, Rahman I.Dysregulation of mitochondrial complexes and dynamics by chronic cigarette smoke exposure Utilizing MitoQC reporter mice. Mitochondrion. 2022 Mar;63:43-50. doi: 10.1016/j.mito.2022.01.003. Epub 2022 Jan 13.PMID: 35032706
Meehan-Atrash J, Rahman I Novel Δ8-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals.
.Chem Res Toxicol. 2022 Jan 17;35(1):73-76. doi: 10.1021/acs.chemrestox.1c00388. Epub 2021 Dec 10.PMID: 34889611
Gagandeep Kaur, Krishna P Maremanda, Michael Campos, Hitendra S Chand, Feng Li4, Nikhil Hirani, M.A. Haseeb and Irfan Rahman. Distinct exosomal miRNA profiles from BALF and lung tissue from COPD and IPF patient. Int. J. Mol Sci. 2021
Le HHT, Liu CW, Denaro P 3rd, Jousma J, Shao NY, Rahman I, Lee WH.Genome-wide differential expression profiling of lncRNAs and mRNAs in human induced pluripotent stem cell-derived endothelial cells exposed to e-cigarette extract. Stem Cell Res Ther. 2021 Dec 4;12(1):593. doi: 10.1186/s13287-021-02654-6.PMID: 34863290
Shikha Sharma, Qixin Wang, Thivanka M Muthumalage, and Irfan Rahman.
Epithelial ablation of Miro1/Rhot1 GTPase leads to mitochondrial dysfunction and lung inflammation by cigarette smoke. The Cells, 2021
Gagandeep Kaur, Xiangming Ji and Irfan Rahman. SARS-CoV2 infection alters Tryptophan catabolism and phospholipid. Metabolites, 2021
Shaiesh Yogeswaran , Thivanka Muthumalage and Irfan Rahman. Comparative Reactive Oxidative Species (ROS) Content among Disposable Flavored Vape Bars . Toxics
Qixin Wang, Xiangming Ji, and Irfan Rahman. Dysregulated Metabolites Serve as Novel Biomarkers for Metabolic Diseases Caused by Vaping and Cigarette Smoking. Metabolites, 2021
Joseph Lucas, Qixin Wang, Thivanka Muthumalage, Irfan Rahman Multi-walled carbon nanotubes (MWCNTs) cause cellular senescence in TGF-β stimulated lung epithelial cells. Toxics 2021
Gagandeep Kaur, Shaiesh Yogeshwaran, Thivanka Muthumalage, and Irfan Rahman. Persistently increased systemic ACE2 activity and Furin levels are associated with increased inflammatory response in smokers with COVID-19. Frontier Physiol 2021
Krishna Prahlad Maremanda, Isaac Kirubakaran Sundar, Irfan Rahman. Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD. Redox Biology, 2021
Dutta RK, Chinnapaiyan S, Santiago MJ, Rahman I, Unwalla HJ. Gene-specific MicroRNA antagonism protects against HIV Tat and TGF-β-mediated suppression of CFTR mRNA and function. Biomed Pharmacother. 2021 Aug 27;142:112090. Doi 10.1016/j.biopha.2021.112090. PMID: 34463266
Gagandeep Kaur, Isaac K. Sundar, and Irfan Rahman. p16-3MR: a novel model to study cellular senescence in cigarette smoke-induced lung injuries during aging. In J Mol Sci, 2021
Qixin Wang, Isaac K. Sundar, and Irfan Rahman. Molecular Clock Rev-erbα regulates Cigarette Smoke-Induced Pulmonary Inflammation and Epithelial-Mesenchymal-Transition. J Clin Inves Insight 2021
Francesca Polverino, MD, PhD Tianshi David Wu, MD, MHS Joselyn Rojas-Quintero, MD
Xiaoyun Wang, PhD Jonathan Mayo Michael Tomchaney Judy Tram Samuel Packard, PhD Duo Zhang, PhD Kristan H. Cleveland Elizabeth Cordoba-Lanus, PhD Caroline A. Owen, MD, PhD Ashraf Fawzy, MD, MPH Greg L. Kinney, PhD, MPH Craig P. Hersh, MD, MPH Nadia N. Hansel, MD MPH Kevin Doubleday Maor Sauler, MD Yohannes Tesfaigzi, PhD Julie G. Ledford, PhD Ciro Casanova, MD Jaroslaw Zmijewski, PhD John Konhilas, PhD Paul R. Langlais, PhD Rick Schnellmann, PhD Irfan Rahman, PhD Meredith McCormack, MD, MHS Bartolome Celli, MD. Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. Am J Respir Crit Care Med In Press 2021
Gagandeep Kaur, Kameshwar Singh, Krishna P. Maremanda, Dongmei Li, Hitendra S. Chand and Irfan Rahman.. Differential plasma exosomal long non-coding RNAs expression profiles and their emerging role in E-cig users, cigarette, waterpipe, and dual smokers. PLoS One 2020
Gina Fong, Suhita Gayen Nee’ Betal, Swati Murthy, Michael Favara, Joanna SY Chan, Sankar Addya, Thomas H Shaffer, Jay Greenspan, Vineet Bhandari, Dongmei Li, Irfan Rahman, Zubair H Aghai. DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes from Term Neonates: Effects of Histological Chorioamnionitis. Frontiers in Pediatrics, section Neonatology 2020
Krishna P. Maremanda, Isaac K. Sundar, Dongmei Li and Irfan Rahman. Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis. Scientific Reports 2020
Qixin Wang, Isaac K. Sundar, Jason L. Blum, Jill R. Ratner, Joseph H. Lucas Tsai-Der Chuang, Ying Wang , Jie Liu, Virender K. Rehan, Judith T. Zelikoff and Irfan Rahman Prenatal exposure to e-cigarette aerosols leads to sex-dependent pulmonary extracellular matrix remodeling and myogenesis in offspring mice. Am J Respir Cell Mol Biol. 2020
Qixin Wang, Isaac K. Sundar, Dongmei Li, Joseph H. Lucas, Thivanka Muthumalage, Samantha R. McDonough, and Irfan Rahman. E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR α7 Receptor: Role of nAChR α7 in ACE2 Covid-19 receptor regulation. Respir Res 2020
Kameshwar P. Singh, DVM; MVSc; Krishna P. Maremanda, Ph.D.; Dongmei Li, Ph.D.; Irfan Rahman, Ph.D. Exosomal microRNAs are novel circulating biomarkers in cigarette, waterpipe smokers, E-cigarette users and dual smokers D. BMC Medical Genomics. 2020
Liane M. Schneller, Dongmei Li, Zahíra Quiñones Tavárez, Maciej L. Goniewicz,
Amanda J. Quisenberry, Zidian Xie, Irfan Rahman, Scott McIntosh, Richard J. O’Connor, Deborah J. Ossip. Flavor Inconsistencies between Flavored Tobacco Products among US Adults. AJHB 2020
Liane M. Schneller, Zahíra Quiñones Tavárez, Maciej L. Goniewicz, PhD, Zidian Xie, Scott McIntosh, Irfan Rahman, Richard J. O’Connor, Deborah J. Ossip, Dongmei Li. Association between exclusive and concurrent use of the three most popular tobacco products and wheezing symptoms among US adults. Nic Tob Res. 2020
Tariq A Bhat, Suresh G Kalathil, Noel Leigh, Thivanka Muthumalage, Irfan Rahman, Maciej L Goniewicz and Yasmin M Thanavala. Acute effects of heated tobacco product (IQOS) aerosol inhalation on inflammatory changes in the lungs. Nic Tob Res, 2020
Thomas Lamb, and Irfan Rahman. Pod based menthol e-cigarettes cause mitochondrial dysfunction in lung epithelial cells. Tox Letters, 2020.
Xie Z, Ossip DJ, Rahman I, Li D.Xie Z, et al. Among authors: Rahman I.Use of Electronic Cigarettes and Self-Reported Chronic Obstructive Pulmonary Disease Diagnosis in Adults. Nicotine Tob Res. 2020 Jun 12;22(7):1155-1161. doi: 10.1093/ntr/ntz234.Nicotine Tob Res. 2020. PMID: 31830263
McGraw MD, Kim SY, Reed C, Hernady E, Rahman I, Mariani TJ, Finkelstein JN.McGraw MD, et al. Among authors: Rahman I. Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure. Toxicol Lett. 2020 Jun 1;325:25-33. doi: 10.1016/j.toxlet.2020.02.012. Epub 2020 Feb 26.Toxicol Lett. 2020. PMID: 32112875
Muthumalage T, Friedman MR, McGraw MD, Ginsberg G, Friedman AE, Rahman I. Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI). Toxics. 2020 Apr 3;8(2):E25. doi: 10.3390/toxics8020025.
Thivanka Muthumalage, Joseph Lucas, Qixin Wang, Thomas Lamb, Mathew McGraw, Irfan Rahman. Pulmonary toxicity and inflammatory response of e-cigarettes vape cartridges containing medium-chain triglycerides oil and vitamin E acetate:
Implications in the pathogenesis of EVALI but independent of SARS-COV-2
COVID-19 related proteins. Toxics 2020
Joseph Lucas, Thivanka Muthumalage, Qiin Wang, Michelle R Friedman, Alan Eric Friedman, Irfan Rahman. E-liquid containing a mixture of coconut, vanilla, and cookie flavors causes cellular senescence by dysregulated repair in pulmonary fibroblasts: Implications on premature aging Journal: Frontiers in Physiology, section Clinical and Translational Physiology 2020
Dongxia Ye, Sangeeta Gajendra, Gina Lawyer, Neelam Jadeja, Deepa Pishey, Srinivasa Pathagunti, Janet Lyons, Peter Veazie, Gene Watson, Scott McIntosh, and Irfan Rahman
Inflammatory Biomarkers and Growth Factors in Saliva and Gingival Crevicular Fluid of E-cigarette users, Cigarette smokers, and Dual smokers: A pilot study. J of Periodontology 2020
Zidian Xie, Deborah J Ossip, Irfan Rahman, Dongmei Li.
Association of electronic cigarette use with COPD in adults. Nicotine Tobacco Research, 2020
Kameshwar P. Singh, Gina Lawyer, Thivanka Muthumalage, Krishna P. Maremanda, Naushad Ahmad Khan, Samantha R McDonough, Dongxia Ye, Scott McIntosh, and Irfan Rahman
Systemic biomarkers of inflammation, oxidative stress, pro-resolving lipid mediators, triglycerides, growth factors, and tissue injury in electronic cigarette users: implications for non-invasive assessment of vaping associated pulmonary injuries. Eur Respir J. Open 2020
Monica Jackson, Kameshwar P. Singh, Thomas Lamb, Scott McIntosh, and Irfan Rahman
Flavors and immunoglobulin responses in E-cigarette users, and waterpipe and tobacco smokers.International Journal of Environmental Research and Public Health, 2020.
Isaac K. Sundar, Dongmei Li, and Irfan Rahman. Small RNA-sequence analysis of Plasma-derived Extracellular Vesicle miRNAs in Smokers and Patients with Chronic Obstructive Pulmonary Disease as circulating biomarkers. Journal of Extracellular Vesicles, 2019
Monica Jackson, Gina Lawyer, Melanie Prinz, Thivanka Muthumalage, and Irfan Rahman
Phylogenic classification of flavors in cigarillos and mini cigars and their variable cellular and acellular oxidative and cytotoxic responses. PLoS One 2019
Krishna Prahlad Maremanda, Isaac K. Sundar and Irfan Rahman. Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. Toxicol Appl Pharmacol 2019
Isaac K. Sundar, Dongmei Li, and Irfan Rahman. “Proteomic Analysis of Plasma-derived Extracellular Vesicles in Smokers and Patients with Chronic Obstructive Pulmonary Disease. J Proteomics, 2019
McGraw, Matthew Daniel; Kim, So-Young; Reed, Christina; Hernady, Eric; Rahman, Irfan; Mariani, Thomas; Finkelstein, Jacob N. Diacetyl vapor exposure causes airway basal cell injury with keratin 5 crosslinking and decreased ΔNp63 expression. Tox Sciences, 2019
Chinnapaiyan S., Dutta RK., Nair M., Chand HS, Rahman I, and Unwalla HJ*.TGF-ß1 promotes HIV-1 latency in primary differentiated human bronchial epithelial cells. Sci Report. 2019
Zidian Xie, Deborah J Ossip, Irfan Rahman, Richard J O’Connor, Dongmei Li. Cigarette Use and Risk of Cognitive Deficits in Adults. Nicotine Tobacco Research 2019
Dongmei Li, PhD, Hangchuan Shi, MD, Zidian Xie, PhD, Irfan Rahman, PhD, Scott McIntosh, PhD, Maansi Bansal-Travers, PhD Jonathan P Winickoff, MD, MPH, Jeremy E Drehmer, MPH5, Deborah J Ossip, PhD. Home Smoking and Vaping Policies among US Adult Cigarette Smokers, Vapers, and Dual Users: Results from the Population Assessment of Tobacco and Health (PATH) Study, Wave 3. Am J of Public Health/Preventive Med 2020
Munerah BinShabaib, Shatha Subhi ALHarthi, Zohaib Akram, Junad Khan, Irfan Rahman, Georgios E. Romanos, Fawad Javed. Clinical periodontal status and gingival crevicular fluid cytokine profile among cigarette-smokers, electronic-cigarette users and never-smokers. Archives of Oral Biology, 2019
Isaac K. Sundar, Krishna Maremanda, and Irfan Rahman. Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke. Tox Letters, 2019
Naushad Ahmad Khan, PhD, Gina Lawyer, BS, Qixin Wang, PhD, Samantha R McDonough, BS, Noura O. Kassem, MPH, Flora Kas-Petrus, BS, Nada O.F. Kassem, DrPH, and
Irfan Rahman, PhD. Systemic biomarkers of inflammation, oxidative stress, tissue injury and repair among waterpipe, cigarette, and dual tobacco smokers. Tobacco Control, 2019
Qixin Wang, Naushad Ahmad Khan, Thivanka Muthumalage, Gina R. Lawyer, Samantha R. McDonough, Tsai-Der Chuang, Ming Gong, Isaac K. Sundar, Virender K. Rehan and Irfan Rahman. Dysregulated repair and inflammatory responses by e-cigarette derived inhaled nicotine and humectant propylene glycol in mouse lung and human 3D EpiAirway tissues. FASEB J BioAdvances 2019
Thivanka Muthumalage, Thomas Lamb, and Irfan Rahman. JUUL and JUUL compatible flavors induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes. Sci Report 2019.
Thivanka Muthumalage and Irfan Rahman. Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts. Tox Appl Pharmacol, 2019
Amr Alderawi, Gaetano Caramori, Emma Baker, Irfan Rahman, Ian Adcock, Alberto Papi, Victor E. Ortega, Jeffrey L. Curtis for the SPIROMICS research group,, Simon Dunmore and Paul Kirkham. FN3K expression in COPD: a possible comorbidity factor with linkage to cardiovascular function. Eur Repir J. In review, 2020.
Suhita Gayen nee’ Betal, Swati Murthy, Michael Favara, Gina Fong, Joanna SY Chan, Sankar Addya, Thomas H Shaffer, Jay Greenspan, Vineet Bhandari, Irfan Rahman, Zubair H. Aghai. Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates. Scientific Report, 2019 Apr 10;9(1):5862. doi: 10.1038/s41598-019-42205-x. PMID: 30971730
Khan NA, Yogeswaran S, Wang Q, Muthumalage T, Sundar IK, Rahman I.
Waterpipe smoke and e-cigarette vapor differentially affect circadian molecular clock gene expression in mouse lungs. PLoS One. 2019 Feb 27;14(2):e0211645. doi: 10.1371/journal.pone.0211645. eCollection 2019. PMID:30811401
Li D, Sundar IK, McIntosh S, Ossip DJ, Goniewicz ML, O’Connor RJ, Rahman I.
Association of smoking and electronic cigarette use with wheezing and related respiratory symptoms in adults: cross-sectional results from the Population Assessment of Tobacco and Health (PATH) study, wave 2. Tob Control. 2019 Feb 13. pii: tobaccocontrol-2018-054694. doi: 10.1136/tobaccocontrol-2018-054694. [Epub ahead of print] PMID:30760629
Liane M. Schneller1, Scott McIntosh, Dongmei Li, Irfan Rahman, Deborah Ossip, Maciej Goniewicz, Richard J. O’Connor. Tobacco use and chemosensory impairments among current adult tobacco users in the US: Data from NHANES 2013–2014. Tob. Induc. Dis. 2018;16(August):xx https://doi.org/10.18332/tid/xxxxx
ALHarthi SS, BinShabaib M, Akram Z, Rahman I, Romanos GE, Javed F.Impact of cigarette smoking and vaping on the outcome of full-mouth ultrasonic scaling among patients with gingival inflammation: a prospective study. Clin Oral Investig. 2018 Oct 26. doi: 10.1007/s00784-018-2725-2. [Epub ahead of print] PMID: 30361795
Snow E, Johnson T, Ossip DJ, Williams GC, Ververs D, Rahman I, McIntosh S. Does E-cigarette Use at Baseline Influence Smoking Cessation Rates among 2-Year College Students?
J Smok Cessat. 2018 Jun;13(2):110-120. doi: 10.1017/jsc.2017.11. Epub 2017 Jun 28.PMID:30034554
Rashid K, Sundar IK, Gerloff J, Li D, Rahman I. Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema. Sci Rep. 2018 Jun 13;8(1):9023. doi: 10.1038/s41598-018-27209-3. PMID: 29899396
Sundar IK, Rashid K, Gerloff J, Rangel-Moreno J, Li D, Rahman I. Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema. FASEB J. 2018 Apr 9:fj201701518R. doi: 10.1096/fj.201701518R. [Epub ahead of print] PMID: 29630406
Sundar IK, Rashid K, Gerloff J, Li D, Rahman I. Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema. Am J Respir Cell Mol Biol. 2018 Feb 15. doi: 10.1165/rcmb.2017-0390OC. [Epub ahead of print] PMID: 29447461
Hanbyeol Lee, Jooyeon Lee, Seok-Ho Hong, Irfan Rahman, Se-Ran Yang
Inhibition of RAGE attenuates cigarette smoke-induced lung epithelial cell damage via RAGE-mediated Nrf2/DAMP signaling. Frontiers in Pharmacology, section Respiratory Pharmacology. In press, 2018
Eddingsaas N, Pagano T, Cummings C, Rahman I, Robinson R, Hensel E. Qualitative Analysis of E-Liquid Emissions as a Function of Flavor Additives Using Two Aerosol Capture Methods. Int J Environ Res Public Health. 2018 Feb 13;15(2). pii: E323. doi: 10.3390/ijerph15020323. PMID: 29438289
Khan NA, Sundar IK, Rahman I. Strain- and sex-dependent pulmonary toxicity of waterpipe smoke in mouse. Physiol Rep. 2018 Feb;6(3). doi: 10.14814/phy2.13579. PMID: 29417753
Muthumalage T, Prinz M, Ansah KO, Gerloff J, Sundar IK, Rahman I.
Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine. Front Physiol. 2018 Jan 11;8:1130. doi: 10.3389/fphys.2017.01130. eCollection 2017. PMID: 29375399
Tang M, Ji C, Pallo S, Rahman I, Johnson GVW.
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.Neurobiol Aging. 2018 Mar;63:128-139. doi: 10.1016/j.neurobiolaging.2017.12.001. Epub 2017 Dec 9 PMID: 29304346
Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM.
Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice.
Sci Rep. 2018 Apr 10;8(1):5746. doi: 10.1038/s41598-018-24166-9. PMID: 29636532
Isaac K Sundar; Qiangzong Yin; Brian Baier; Li Yang; Witold Mazur; Dongmei Li; Martha Susiarjo; Irfan Rahman. DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. Clinical Epigenetics, 2017
Snow E, Johnson T, Ossip DJ, Williams GC, Ververs D, Rahman I, McIntosh S (Under Review). Does E-Cigarette Use at Baseline Influence Smoking Cessation Rates among Two-Year College Students? Journal of Smoking Cessation. 2017
Fawad Javed, Tariq Abduljabbar, Fahim Vohra, Hans Malmstrom, Irfan Rahman, Georgios E. Romanos. Comparison of Periodontal Parameters and Self-Perceived Oral Symptoms among Individuals Vaping Electronic-Cigarettes, Cigarette-smokers and Never-smokers: A Pilot Study. J of Periodontology, 2017.
Fawad Javed, Tariq Abduljabbar, Fahim Vohra, Irfan Rahman‡, Hans Malmstrom, Georgios E. Romanos Oral soft tissue response to Supragingival plaque control among cigarette smokers, individuals vaping electronic cigarettes and never smokers with periodontal inflammation. J of Periodontology, 2017 (In review).
Lei Wei, Chad A. Lerner, Isaac K. Sundar, and Irfan Rahman. Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OxPhos complex III. Nature Scientific Rep 2017
Janice Gerloff MS, Chad A. Lerner Ph. D, Robert Freter, Risa Robinson, PhD., Irfan Rahman., Inflammatory effects of different e-cigarette flavors on lung epithelial cells. Applied In Vitro Toxicology. 2017
Sameer Arbat, Mitesh Dave, Vinit Niranjane, Irfan Rahman, and Ashok Arbat/ Changing clinical profile of Influenza A H1N1 in central India – A retrospective analysis and study Virus Disease 2017
Hanbyeol Lee, Jeong-Ran Park, Woo Jin Kim, Isaac K. Sundar, Irfan Rahman, Seok-Ho Hong, Sung-Min Park, Se-Ran Yang. Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling. FASEB J, 2017
Lerner CA, Rutagarama P, Sundar I, Rahman I. Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts Biochem Biophys Res Commun. 2016 Jun 23. pii: S0006-291X(16)31027-0. doi: 10.1016/j.bbrc.2016.06.109. PubMed PMID: 27343559
Isaac K. Sundar,, Chad A. Lerner, Lei Wei, Fawad Javed, Janice Gerloff, Sangeeta Gajendra, Gene Watson, Georgios E Romanos, Irfan Rahman. E-cigarettes and nicotine induce inflammatory and dysregulated repair responses in oral epithelial cells and periodontal fibroblasts. Oncotarget 2016
Isaac K. Sundar, Qiangzong Yin, Martha Susiarjo, Dongmei Li and *Irfan Rahman. DNA methylation profile in lungs of patients with COPD: Severity predicting exacerbations. Clinical Epigenetics 2016
Tanveer Ahmad, Isaac K. Sundar, Ana M. Tormos, Janice Gerloff, Chad A. Lerner, Witold Mazur, and Hongwei Yao, Irfan Rahman. Shelterin TPP1 reduction causes telomere attrition and cellular senescence in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2016. Cover page.
Isaac K. Sundar and Irfan Rahman. Gene expression profiling, network and canonical pathways analysis of epigenetic chromatin modification enzymes by cigarette smoke. Am J Physiol: Lung 2016
Fawad Javed, Abdulaziz A. Al-Kheraif, Irfan Rahman, Lorena Teresa Millan-Luongo, Khalid M. Aldosary, Michael Yunker, Hans Malmstrom, Georgios E. Romanos. Comparison of clinical and radiographic periodontal status among habitual waterpipe smokers and cigarette smokers Journal of Clinical Periodontology. 2015 Oct 2:1-9. [Epub ahead of print] PMID:26430928
Todd Pagano; A. Gary DiFrancesco; Susan B. Smith; Jerrin George; Gloria Wink; Irfan Rahman; Risa J. Robinson. Determination of Nicotine Content and Delivery in Disposable Electronic Cigarettes Available in the USA by Gas Chromatography-Mass Spectrometry. Nicotine & Tobacco Research 2015; doi: 10.1093/ntr/ntv120
Isaac K. Sundar, Tanveer Ahmad, Hongwei Yao, Jae-woong Hwang, Janice Gerloff, B Paige Lawrence, Michael T. Sellix, and Irfan Rahman. Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD. Sci Rep 2015 Apr 29;4:9927. doi: 10.1038/srep09927. PMID: 25923474
Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I.
Disruption of SIRT1-mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2015 Apr 23. [Epub ahead of print] PMID: 25905433
Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, Rahman I. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: Implications for chronic obstructive pulmonary disease. FASEB J. 2015, pii: fj.14-268276. PMID: 25792665
Chad A. Lerner, Isaac K. Sundar, Hongwei Yao, Janice Gerloff, Deborah J. Ossip, Scott McIntosh, Risa Robinson, Irfan Rahman. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One. 2015 Feb 6;10(2):e0116732. doi: 10.1371/journal.pone.0116732. eCollection 2015.PMID:25658421 (More than 130,000 hits)
Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I. Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols. Environ Pollut. 2015 Jan 8;198C:100-107. PMID: 25577651
Yao H, Sundar IK, *Ahmad T, Lerner C Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente LP, Rahman I. SIRT1 protects against cigarette smoke-induced lung oxidative stress via FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 2014;306(9):L816-28.PMID 24633890
Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. FASEB J. 2013 Sep 11. PMID:24025728. Selected for Cover Page of Jan 2014 issue.
Chulman Jo, Soner Gundemir, Susanne Pritchard, Youngnam N. Jin, Irfan Rahman, Gail V.W. Johnson. Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. Nature Communications 2014, PMID: 24667209
Sundar IK, Nevid MZ, Friedman AE, Rahman I. Cigarette smoke induces distinct chromatin histone modifications in lung cells: implication in pathogenesis of COPD and lung cancer. J Proteome Res. 2013 Nov 27. [Epub ahead of print] PMID:24283195. Selected for Cover Page of Feb 2014 issue.
Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, and Rahman I. Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: Implication for COPD-associated neuropathogenesis. PLoS One. 2014 Feb 10;9(2):e87999. doi: 10.1371/journal.pone.0087999
Yao H, Sundar IK, Gorbunova V, Rahman I. P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence. PLoS One. 2013 Nov 11;8(11):e80007. PMID:24244594
Yao H, *Hwang JW, *Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, and Rahman I. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol. 305: L615-624, 2013. PMID: 24039251, PMCID: 3840276
Gilels F, Paquette S, Zhang J, Rahman I, White P. Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse artichitecture in mice. J. Neurosceince, 2013 Nov 20;33(47):18409-24. doi: 10.1523/JNEUROSCI.2529-13.2013. PMID: 24259566 [PubMed – in process]
Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest. 2013, PMID: 24200693
Amit Agarwal, Liqin Zhao, Harsh Sancheti, Isaac Sundar, Irfan Rahman, and Enrique Cadenas. Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory response in mouse lung. Am J Physiol Lung Cell Mol Physiol. 303: L889-98, 2013, PMID 23064950
Vladimir T. Basic, Elsa Tadele, Ali Ateia Elmabsout, Hongwei Yao, Irfan Rahman, Allan Sirsjö and Samy M. Abdel-Halim. Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle. Am J Physiol Lung Cell Mol Physiol. 303:L519-L527, 2012.
Hongwei Yao, Sangwoon Chung*, Jae-woong Hwang*, Saravanan Rajendrasozhan, Isaac K Sundar*, David A. Dean, Michael W. McBurney, Leonard Guarente, Wei Gu, Mikko Rönty, Vuokko L. Kinnula, and Irfan Rahman. SIRT1 protects against pulmonary emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest 122:2032-2045, 2012. Selected for Faculty of 1000 Medicine.
Sundar IK*, Chung S*, Hwang JW*, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. Mitogen- and Stress-Activated Kinase 1 (MSK1) Regulates Cigarette Smoke Induced Histone Modifications on NF-κB-dependent Genes. PLoS One 7(2):e31378, 2012.
Sergiy M. Nadtochiy, Yao Hongwei, Michael W. McBurney, Wei Gu, Leonard Guarente, Irfan Rahman, Paul S. Brookes. SIRT1 mediated acute cardioprotection. Am J Physiol: Heart and Circ, 301(4):H1506-12, 2011
Hwang JW*, Rajendrasozhan S*, Yao H*, Chung S*, Sundar IK*, Kinnula VL, Rahman I. FoxO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol. 187(2):987-98, 2011.
Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL. Smoking and COPD increase sputum levels of ECSOD.Free Radic Biol Med. 51(3):726-32; 2011.
Chung S*, Sundar IK*, Hwang JW*, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, and Rahman I. NF-κB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFα-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs. PloS One. 6: e23488. PMID:21887257, 2011.
Sundar IK*, Hwang JW*, Wu S, Sun J, Rahman I. Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation. Biochem Biophys Res Comm. 406: 127-133, 2011.
Londhe VA, Sundar IK*, Lopez B, Maisonet TM, Yu Y, Aghai ZH, Rahman I. Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and upregulation of p21 in neonatal mouse lung. Pediatr Res. 69: 371-377, 2011
Adenuga D*, Caito S*, Yao H*, Sundar IK*, Hwang JW*, Chung S*, Rahman I. Nrf2 Deficiency influences susceptibility to steroid resistance via HDAC2 reduction. Biochem Biophys Res Commun. 403 (3-4): 452-456, 2010.
Sundar IK*, Chung S*, Hwang JW*, Arunachalam G*, Cook S, Yao H*, Mazur W, Kinnula VL, Fisher AB, Rahman I. Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke-mediated lung inflammatory response and injury. Exp Lung Res. 36:451-62; 2010.
Ishikawa N, Ohlmeier S, Salmenkivi K, Myllärniemi M, Rahman I, Mazur W, Kinnula VL. Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD. Respir Res. 11:123; 2010.
Nadtochiy SM, Redman E, Rahman I, Brookes PS. Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res. 89; 643-649, 2010.
Yao H, Arunachalam G*, Hwang JW*, Chung S*, Sundar IK*, Kinnula VL, Crapo JD, Rahman I. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A. 107:15571-6; 2010.
Arunachalam G*, Sundar IK*, Hwang JW*, Yao H*, Rahman I. Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. J Inflamm (Lond). 7:34; 2010.
Hwang JW*, Chung S*, Sundar IK*, Yao H*, Arunachalam G*, McBurney MW, Rahman I. Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys. 500:203-9; 2010.
Chung S*, Sundar IK*, Yao H*, Ho YS, Rahman I. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. Am J Physiol Lung Cell Mol Physiol. 299:L192-203; 2010.
Adenuga D*, Rahman I. Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch Biochem Biophys. 498:62-73; 2010.
Caito S*, Rajendrasozhan S*, Cook S, Chung S*, Yao H*, Friedman AE, Brookes PS, Rahman I. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 24:3145-59; 2010.
Marwick JA*, Edirisinghe I*, Arunachalam G*, Stevenson CS, MacNee W, Kirkham PA, Rahman I. Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs. J Inflamm (Lond). 7:11; 2010.
Arunachalam G*, Yao H*, Sundar IK*, Caito S, Rahman I. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun. 393:66-72; 2010.
Rajendrasozhan S*, Hwang JW*, Yao H*, Kishore N, Rahman I. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther. 23:172-81; 2010.
Bancos S, Baglole CJ, Rahman I, Phipps RP. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. Cell Immunol. 262:18-27; 2010.
Caito S*, Hwang JW*, Chung S*, Yao H*, Sundar IK*, Rahman I. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity. Biochem Biophys Res Commun. 392:264-70; 2010.
Yao H*, Hwang JW*, Moscat J, Diaz-Meco MT, Leitges M, Kishore N, Li X, Rahman I. Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J Biol Chem. 285:5405-16; 2010.
Vibhuti A, Arif E, Deepak D, Singh B, Rahman I and Pasha MAQ. Cyp1A1, Cyp1A2 and Cyba gene polymorphisms associated with oxidative stress in COPD. Clin Chim Acta 411(7-8):474-80; 2010.
Rajendrasozhan S*, Chung S*, Sundar IK*, Yao H*, Rahman I. Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. Am J Physiol Lung Cell Mol Physiol. 298:L197-209; 2010.
Zakkar M, Van der Heiden K, Luong le A, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC, Evans PC. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol. 29:1851-7; 2009.
Sarir H, Mortaz E, Karimi K, Kraneveld AD, Rahman I, Caldenhoven E, Nijkamp FP, Folkerts G. Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages. J Inflamm (Lond). 6:12; 2009.
Adenuga D*, Yao H*, March TH, Seagrave J, Rahman I. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol. 40: 464-73; 2009.
Yang SR*, Yao H*, Rajendrasozhan S*, Chung S*, Edirisinghe I*, Valvo S, Fromm G, McCabe MJ Jr, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. Am J Respir Cell Mol Biol. 40:147-58; 2009.
Yang SR*, Valvo S*, Yao H*, Kode A*, Rajendrasozhan S*, Edrisinghe I*, Caito S*, Adenuga D*, Henry R*, Fromm G, Maggirwar S, Li JD, Bulger MD, Rahman I, IKK causes chromatin modification on pro-inflammatory promoters by cigarette smoke in mouse lung. Am J Respir Cell Mol Biol. 38: 689-698; 2008.
Edirisinghe I*, Yang SR*, Hongwei Yao*, Rajendrasozhan S*, Caito S*, Adenuga D*, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I, VEGFR2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J., 22:2297-2310, 2008.
Yao H*, Edirisinghe I*, Yang SR*, Rajendrasozhan S*, Kode A*, Caito S, Adenuga D*, Rahman I. Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and injury in mice. Am J. Pathol. 172: 1222-1237; 2008.
Yao H*, Yang SR*, Edirisinghe I*, Rajendrasozhan S*, Caito S*, Adenuga D*, O’Reilly M, Rahman I. Disruption of p21CIP1/WAF1/SDI1 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice. Am J Respir Cell Mol Biol. 39: 7-18; 2008. Selected for Faculty of 1000 Medicine.
Yao H*, Edirisinghe I*, Rajendrasozhan S*, Yang SR*, Caito S*, Adenuga D*, Rahman I. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol. 294:L1174-L1186; 2008.
Kode A*, Rajendrasozhan S*, Caito S*, Yang SR*, Megson IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol.294: L478-L488; 2008.
Rajendrasozhan S*, Yang SR*, Kinnula VL, Rahman I. SIRT1, an Anti-Inflammatory and Anti-Aging Protein, is Decreased in Lungs of Patients with COPD. Am J Respir Crit Care Med. 177: 861-870; 2008.
Meja, K.K, Rajendrasozhan S*, Adenuga D*, Kirkham, P.A., G. Spooner, J.A. Marwick, C.P. Fletcher, P. Whittaker, I.L. Megson, Kirkham, P.A., and I. Rahman. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol. 39: 312-323; 2008.
Caito S*, Yang SR*, Kode A*, Edirisinghe I*, Rajendrasozhan S*, Phipps RP, Rahman I. Rosiglitazone and 15-Deoxy-Delta(12,14)-Prostaglandin J(2), PPARgamma Agonists, Differentially Regulate Cigarette Smoke-Mediated Pro-Inflammatory Cytokine Release in Monocytes/Macrophages. Antioxid Redox Signal. 10:253-60, 2008.
Ryan EP, Bushnell TP, Friedman AE, Rahman I, Phipps RP. Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. Cancer Immunol Immunother. 57:347-58, 2008.
Debret R, Brassart-Pasco S, Lorin J, Martoriati A, Deshorgue A, Maquart Francois-Xavier, Hornebeck W, Rahman I, Antonicelli F. Ceramide inhibition of MMP-2 expression and human cancer bronchial cells invasiness involves decreased histone acetylation. Biochem Biophys Acta, 1783:1718-1727, 2008.
Aghai ZH, Kode A*, Saslow JG, Nakhla T, Farhath S, Stahl GE, Eydelman R, Strande L, Leone P, Rahman I. Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants. Pediatr Res. 2007 62:483-8, 2007.
Yang SR*, Wright J, Bauter M, Seweryniak K, Kode A*, Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol. 292:L567-76, 2007.
Tambyraja AL, Mitchell R, Driscoll PJ, Deans C, Parks RW, Rahman I, Megson IL. Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunction: potential advantages of S-nitrosoglutathione supplementation. Transplant Immunol. 18: 146-150, 2007.
Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, Bultler K. Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation. Am J Physiol Lung Cell Mol Physiol. 293:L1183-93, 2007.
Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. NatureProtocol. 1:3159-65, 2006.
Marwick JA, Stevenson CS, Giddings J, MacNee W, Butler K, Rahman I, Kirkham PA. Cigarette smoke disrupts VEGF165-VEGFR2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol. 290:L897-908, 2006.
Kode, A*, S.R. Yang*, and I. Rahman. Differential effects of cigarette smoke on oxidative stress pro-inflammatory cytokine release in human primary airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir. Res. 7:132-152, 2006.
Yang, S.R*, A.S. Chida*, M.R. Bauter, N. Shafiq, K. Seweryniak*, S.B. Maggirwar, I. Kilty, and I. Rahman. Cigarette smoke induces pro-inflammatory cytokine release by activation of NF-B and post-translational modifications of histone deacetylase in macrophages. Am. J. Physiol. Lung Cell Mol. Physiol. 291:L46-57, 2006.
Aghai, Z.H., S. Kumar, S. Farhath, M.A. Kumar, J. Saslow, T. Nakhla, R. Eydelman, L. Strande, G. Stahl, C. Hewitt, M. Nesrin, and I. Rahman. Dexamethasone suppresses expression of nuclear factor -kappaB in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress. Pediatr. Res. 59:811-815, 2006.
Baglole, C.J., S.M. Bushinksy, T.M. Garcia, A. Kode*, I. Rahman, P.J. Sime, and R.P. Phipps. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast stains: implications for emphysema. Am. J. Physiol. Lung Cell Mol. Physiol. 291:L19-29, 2006.
Morrison, D., I. Rahman, and W. MacNee. Epithelial permeability, inflammation and oxidant status in airspace epithelium following exposure to ozone. Respir. Med. 100:2227-2234, 2006.
Biswas, S.K.*, C.S. Anderson, I.L. Megson, and I. Rahman. Curcumin induces glutathione biosynthesis and inhibits oxidant- and TNF-a-mediated NF-B activation and chromatin remodeling in alveolar epithelial cells. Antioxid. Redox Signal. 7:32-41, 2005.
Echazarreta, A.L., I. Rahman, E. Sala, V. Peinado, J.A. Barbera, W. MacNee, and R. Rodriguez-Roisin. Effects of platelet-activating factor challenge on oxidant-antioxidant balance and exhaled nitric oxide in mild asthma. Respir. Med. 99:510-523, 2005.
Luppi, F., J. Aarbiou, S. van Weterin, I. Rahman, W.I. de Boer, K. Rabe, and P.S. Hiemstra. Cigarette smoke condensate increases proliferation of airway epithelial cells: role of glutathione. Respir. Res. 6:140, 2005.
Biswas, S.K.*, D. Newby, I. Rahman, and I.L. Megson. Glutathione deficiency in Apo-E-/- mice an early event that precedes oxidative stress and atherogenesis. Biochem. Biophys. Res. Commun. 338:1368-1373, 2005.
Marwick, J.A.*, J. Giddings, K. Butler, P. Kirkham, K. Donaldson, W. MacNee, and I. Rahman. Cigarette smoke induces inflammatory response and alters chromatin remodeling in rat lungs. Am. J. Respir. Cell Mol. Biol. 31:633-642, 2004.
Moodie, F.*, J.A. Marwick, C. Anderson, P. Szulakowski, S. Biswas, I. Kilty and I. Rahman. Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-B activation and pro-inflammatory cytokine release in alveolar epithelial cells. FASEB J. 18:1897-1899, 2004.
Antonicelli, F., M. Parmentier, E.M. Drost, N. Hirani, I. Rahman, K. Donaldson, and W. MacNee. Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol anti-oxidant Nacystelyn. Am. J. Physiol. Lung Cell Mol. Physiol. 286:L1319-1327, 2004.
Kirkham, P.A., G. Spooner, I. Rahman, and A.G. Rossi. Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products. Biochem. Biophys. Res. Commun. 318:32-37, 2004.
Lim, S.Y., J.H. Jang, S.C. Lu, I. Rahman, and Y.J. Surh. 15-Deoxy-Δ12,14-Prostaglandin J2 protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. J. Biol. Chem. 279:46263-46270, 2004.
Gilmour, P.S., I. Rahman, K. Donaldson, and W. MacNee. Environmental particle-mediated epithelial IL-8 release is regulated by histone acetylation. Am. J. Physiology. Lung Cell Mol. Physiol. 284:L533-L540, 2003.
Rahman, I., P.S. Gilmour, L.A. Jimenez, F. Antonicelli, and O.I. Aruoma. Ergothioneine inhibits oxidative stress and TNF- induced NF-B/AP-1 binding and interleukin-8 release in alveolar epithelial cells. Biochem. Biophys. Res. Commun. 302:860-864, 2003.
Wickenden, J.A.*, A.G. Rossi, I. Rahman, S.P. Faux, K. Donaldson, and W. MacNee. Cigarette smoke switches apoptosis to necrosis. Am. J. Respir. Cell Mol. Biol. 29:562-570, 2003.
Busquets, X., M. Morla, I. Rahman, R. Motterlini, C. Saus, P. Garcia, C. Miralles, B. Morales-Nin, and A.G.N. Agusti. Nitric oxide synthase type I (nNOS), vascular endothelial growth factor (VEGF) and myoglobin-like expression in skeletal muscle of Antarctic icefishes (Notothenioidei: Channichthyidae). Polar Biol. 26:458-462, 2003.
Debret, R., H. El Btaouri, L. Duca, I. Rahman, S. Radke, B. Haye, J.M. Sallenave, and F. Antonicelli. Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells. FEBS Lett. 546:195-202, 2003.
Jardine, H.*, W. MacNee, K. Donaldson, and I. Rahman. Molecular Mechanism of TGF-β1-induced Glutathione Depletion in Alveolar Epithelial Cells Involvement of AP-1/ARE and Fra-1. J. Biol. Chem. 277:21158-21166, 2002.
Rahman, I., P. Gilmour, L.A. Jimenez, and W. MacNee. Oxidative stress and TNF- induce histone acetylation and AP-1/NF-kB in alveolar epithelial cells: potential mechanism in inflammatory gene transcription. Mol. Cell Biochem. 234/235:239-248, 2002.
Rahman, I., W. Annemarie, A.M. van Schadewijk, A.J.L. Crowther, P.S. Hiemstra, J. Stolk, W. MacNee, and W.I. de Boer. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with COPD. Am. J. Respir. Crit. Care Med. 166:490-495, 2002.
Coe, J.P.*, I. Rahman, N. Sphyris, A.R. Clarke, and D.J. Harrison. Oxidative stress modulates cellular glutathione levels and initiates p53-dependent and independent apoptosis in embryonic stem cells. Free Rad. Biol. Med. 32:187-196, 2002.
Antonicelli, F., M. Parmentier, I. Rahman, E. Drost, N. Hirani, K. Donaldson, and W. MacNee. Nacystelyn inhibits hydrogen peroxide mediated interleukin-8 expression in human alveolar epithelial cells. Free Radic. Biol. Med. 32:492-502, 2002.
Jimenez, L.A., E.M. Drost, P. Gilmour, I. Rahman, F. Antonicelli, H. Ritche, W. MacNee, and K. Donaldson. PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha. Am. J. Physiol. 282:L237-248, 2002.
Gilmour, P.S., I. Rahman, V. Stone, K. Donaldson, and W. MacNee. PM10-mediated IL-8 release from epithelial cells involves histone acetylation. Ann. Occup. Hyg. 46:436-439, 2002.
Marwick, J.*, P. Kirkham, K. Donaldson, W. MacNee, and I. Rahman. Cigarette smoke-induced oxidative stress and TGF-1 increase p21waf1/cip1 expression in alveolar epithelial cells. Ann. N. Y. Acad. Sci. 973:1-6, 2002.
Kim, H.J., X. Liu, H. Wang, T. Kohyama, T. Kobayashi, F.Q. Wen, D.J. Romberger, S. Abe, W. MacNee, I. Rahman, and S.I. Rennard. Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke extract. Am. J. Physiol. Lung Cell Mol. Physiol. 283: L409-L417, 2002.
Deiana, M., M.A. Dessi, B. Ke, Y.F. Liang, T. Higa, P.S. Gilmour, L.S. Jen, I. Rahman, and O.I. Aruoma. The herbal antioxidant cocktail, effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro. Biochem. Biophys. Res. Commun. 296:1148-1151, 2002.
Rahman, I., B. Mulier, P.S. Gilmour, P.K. Jeffery, and W. MacNee. Oxidant-induced lung epithelial cell tolerance: the role of intracellular glutathione and NF-B. Biochem. Pharmacol. 62:787-794, 2001.
Gilmour, P.S., I. Rahman, S. Hayashi, J.C. Hogg, K. Donaldson, and W. MacNee. Adenoviral E1A renders alveolar epithelial cells susceptible to environmental particle-induced transcription of interleukin-8. Am. J. Physiol. 281:L598-L606, 2001.
Rahman, I., E. Swarska, M. Henry, C.M. O’Connor, M.X. FitzGerald, and W. MacNee W. Is there any correlation between antioxidant capacity and lung function in smokers and patients with chronic obstructive pulmonary disease? Thorax. 55:189-193, 2000.
Rahman, I., W.I. Boer, A. Schadewijk, P.S. Heimstra, J. Stolk, J.H.J.M. Krieken, and W.MacNee. Localisation of of -glutamylcysteine synthetase mRNA expression in lungs of smokers and patients with chronic obstructive pulmonary disease. Free Radic. Biol. Med. 28:920-925, 2000.
Jimenez, L.A., J. Thomson, D. Brown, I. Rahman, F. Antonicelli, R.Duffin, R.T. Hay, K. Donaldson, and W. MacNee. Activation of nuclear factor-kappa B by PM10 occurs via an iron-mediated mechanism in the absence of IB degradation. Toxicol. Appl. Pharmacol. 166:101-110, 2000.
Ward, C., T.H. Wong, J. Murray, I. Rahman, C. Haslett, E.R. Chilvers, and A.G. Rossi. Induction of human neutrophil apoptosis by nitric oxide donors: evidence for a caspase-dependent, cyclic-GMP-independent, mechanism. Biochem. Pharmacol. 59:305-314, 2000.
MacKinnon, A.C., I. Rahman, N. Hirani, C. Haslett, and T. Sethi.Antagonist G induces apoptosis in small cell lung cancer cells via ROS mechanisms. Br. J. Cancer Res. 83:941-948, 2000.
Mantle, D., V.B. Patel, H.J.F. Why, S. Ahmed, I. Rahman, W. MacNee, W.S. Wassif, P.J. Richardson, and V.R. Preedy. Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension. Clin. Chim. Acta. 299:1-10, 2000.
Miralles, C., X. Busquets, C. Santos, B. Togores, S. Hussain, I. Rahman, W. MacNee, and A.G.N. Agusti. Regulation of iNOS expression and glutathione levels in rat liver by oxygen tension. FEBS Lett. 476:253-257, 2000.
Parmentier, M., N. Hirani, I. Rahman, K. Donaldson, and F. Antonicelli. Regulation of LPS-mediated IL-1 by N-acetyl-L-cysteine in THP-1 cells. Eur. Respir. J. 16:933-939, 2000.
Rahman, I., F. Antonicelli, and W. MacNee. Molecular mechanism of the regulation of glutathione synthesis by tumour necrosis factor- and dexamethasone in human alveolar epithelial cells. J. Biol. Chem. 274:5088-5096, 1999.
Lapperre, T.L.*, L.A. Jimenez, A. Antonicelli, E. Drost, P.J. Hiemstra, J. Stolk, W. MacNee, and I. Rahman. Apocynin increases glutathione synthesis and activates AP-1 in human alveolar epithelial cells. FEBS Lett. 443:235-239, 1999.
Rahman, I., E. Swarska, M. Henry, M. Davis, C. O’Connor, M. FitzGerald, A. Greening and W. MacNee. Pulmonary and systemic oxidative stress in idiopathic pulmonary fibrosis. Free Radic. Biol. Med. 27:60-68, 1999.
Morrison, D., I. Rahman, S. Lannan, and W. MacNee. Epithelial permeability, inflammation, and oxidant status in the airspaces of smokers. Am. J. Respir. Crit. Care. Med. 159:473-479, 1999.
Schmallenbach, K.S., I. Rahman, H.H.L. Sasse, P.M. Dixon, R.E.W. Halliwell, B.C. McGorum, R. Crameri, and H.R.P. Miller. Studies on pulmonary and systemic Aspergillus fumigatus-specific IgE and IgG antibodies in horses affected with chronic obstructive pulmonary disease (COPD). Vet. Immunol. Immunopath. 66:245-256, 1999.
Rossi, A.G., C. Haslett, N. Hirani, A.P. Greening, I. Rahman, C.N. Metz, R. Bucala, and S.C. Donnelly. Human circulating eosinophils secrete macrophage inhibitory factor (MIF): Potential role in asthma. J. Clin. Invest. 101:2869-2874, 1998.
Rahman, I., C.A.D. Smith, F. Antonicelli, and W. MacNee. Characterisation of -glutamylcysteine synthetase-heavy subunit promoter : A critical role of AP-1. FEBS Lett. 427:120-133, 1998.
Rahman, I., A. Bel, B. Mulier, K. Donaldson and W. MacNee. Differential effects of oxidants and dexamethasone on -glutamylcysteine synthetase and -glutamyl transpeptidase in alveolar epithelial cells. Am. J. Physiol. 275:L80-L86, 1998.
Mulier, B., I. Rahman, T. Watchorn, K. Donaldson, W. MacNee, and P.K. Jeffery. Hydrogen peroxide-induced epithelial injury: the protective role of intracellular non-protein thiols (NPSH). Eur. Respir. J. 11:384-391, 1998.
Gilmour, P.S., D.M. Brown, P.H. Beswick, W. MacNee, I. Rahman, and K. Donaldson. Free radical activity of industrial fibres: role of iron in oxidative stress and activation of transcription factors. Environ. Health Perspect. 105:1313-1317, 1997.
MacNee, W., I. Rahman, X.Y. Li, D. Morrison, and K. Donaldson. Cigarette smoke-induced oxidant/antioxidant imbalance and its role in increased epithelial permeability. Ann. Occup. Hyg. 41:728-735, 1997.
Rahman. I., M.F. Lawson, C.A.D. Smith, D.J. Harrison, and W. MacNee. Induction of -glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells. FEBS Lett. 396:21-25, 1996.
Rahman, I., A. Bel, B. Mulier, M.F. Lawson, D.J. Harrison, W. MacNee, and C.A.D. Smith. Transcriptional regulation of -glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells. Biochem. Biophys. Res. Commun. 229:832-837, 1996.
Rahman, I., D. Morrison, K. Donaldson, and W. MacNee. Systemic oxidative stress in asthma, COPD and smokers. Am. J. Respir. Crit. Care Med. 154:1055-1060, 1996.
Li, X.Y., I. Rahman, K. Donaldson, and W. MacNee. Mechanisms of cigarette smoke-induced increased airspace permeability. Thorax. 51:465-471, 1996.
MacNee, W., D. Morrison, I. Rahman, X.Y. Li, and K. Donaldson. Cigarette Smoke and ozone-induced epithelial perturbation in vivo and in vitro: the role of glutathione. Chest. 109:39S, 1996.
Rahman, I., X.Y. Li, K. Donaldson, D.J. Harrison, and W. MacNee. Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress. Am. J. Physiol. 269:L285-L292, 1995.
Hannah, S., K. Mechlenburgh, I. Rahman, G. Bellingan, A. Greening, C. Hasslett, and E. Chilvers. Hypoxia prolongs neutrophil survival in vitro. FEBS Lett. 372:233-237,1995.
Rahman. I., X.Y. Li, K. Donaldson, and W. MacNee. Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs. Biochem. Soc. Trans. 23:235S, 1995.
Li, X.Y., K. Donaldson, I. Rahman, and W. MacNee. An investigation of the role of glutathione in the increased epithelial permeability induced by cigarette smoke in vivo and in vitro. Am. J. Resp. Cri. Care Med. 149:1519-1525, 1994.
Rahman, I., A. Upadhyay, V. Tule, and N. Nath. Calcium homeostasis of polymorphonuclear leukocytes in diabetes, hypertension and arthritis. Indian J. Clin. Biochem. 10:111-115, 1994.
Rahman, I., A. Upadhyay, V. Tule, and N. Nath. Membrane potentials and phagocytic indices of diabetic, arthritic and hypertensive PMN leukocytes. Indian J. Clin. Biochem. 8:25-31, 1993.
Rahman, I., and N. Nath. Calcium homeostasis and its messenger systems of PMN leukocytes in essential hypertension. Annals Natl. Acad. Med. Sci. (India). 29:75-82, 1993.
Rahman, I., and D. Massaro. Endotoxin treatment protects against ozone induced lung edema: with evidence for the role of Mn-SOD. Toxicol. Appl. Pharmacol. 113:13-18, 1992.
Rahman, I., G.D. Massaro, and D. Massaro. Exposure of rats to ozone : evidence of damage to heart and brain. Free Radic. Biol. Med. 12:323-326, 1992.
Rahman, I., L.C. Clerch, and D. Massaro. Rat lung antioxidant enzyme induction by ozone. Am. J. Physiol. 260:L412-L418, 1991.
Rahman, I., and N. Nath. Lysosomal enzymes of polymorphonuclear leukocytes in essential hypertension. Indian J. Clin. Biochem. 4:1-10, 1989.
Rahman, I., and N. Nath. Glutathione and its redox system, superoxide anion and superoxide dismutases of polymorphonuclear leukocytes in essential hypertension. Indian J. Med. Res. 88:64-70, 1988.
Rahman, I., and N. Nath. Membrane potential and activities of membrane bound enzymes of PMN leukocytes in essential hypertension. Indian J. Biochem. Biophys. 25:326-330, 1988.
Rahman, I., and N. Nath. Possible factors responsible for lysosomal release from normotensive and hypertensive PMN leukocytes. Indian J. Clin. Biochem. 3:118-122, 1988.
Rahman, I., and N. Nath. Polymorphonuclear leukocytic sialic acid in essential hypertension. Indian Heart J. 37:370-372, 1985.