Sun Y, Lin K, Effah F, Cartujano Barrera F, Li D, McIntosh S, McGraw MD, Rahman I. Toxicity of humectants propylene glycol and vegetable glycerin in electronic nicotine delivery systems. Toxicol Lett. 2025 Nov;413:111739. doi: 10.1016/j.toxlet.2025.111739. Epub 2025 Oct 1. Review. PubMed PMID: 41043656; PubMed Central PMCID: PMC12515514.

Panda K, Chinnapaiyan S, Unwalla HJ. Dual inhibition of ACE-2 and TMPRSS2: A promising strategy to mitigate SARS-CoV-2 severity in smokers. Mol Ther Nucleic Acids. 2025 Sep 9;36(3):102662. doi: 10.1016/j.omtn.2025.102662. eCollection 2025 Sep 9. PubMed PMID: 40896581; PubMed Central PMCID: PMC12397935.

Effah F, Sun Y, Friedman A, Rahman I. Emerging nicotine analog 6-methyl nicotine increases reactive oxygen species in aerosols and cytotoxicity in human bronchial epithelial cells. Toxicol Lett. 2025 Mar;405:9-15. doi: 10.1016/j.toxlet.2025.01.007. Epub 2025 Feb 1. PubMed PMID: 39894318; PubMed Central PMCID: PMC11875870.

Li D, Xie Z, Shaikh SB, Rahman I. Altered expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users. Sci Rep. 2025 Jan 21;15(1):2714. doi: 10.1038/s41598-025-85373-9. PubMed PMID: 39837838; PubMed Central PMCID: PMC11751386.

Faizan MI, Kaur G, Shaikh SB, Effah F, Unwalla H, Rahman I. Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice. Physiol Rep. 2025 Jan;13(2):e70199. doi: 10.14814/phy2.70199. PubMed PMID: 39844449; PubMed Central PMCID: PMC11754243.

Panda K, Santiago MJ, Rahman MS, Ghorai S, Black SM, Rahman I, Unwalla HJ, Chinnapaiyan S. HIV-1 Tat Protein and Cigarette Smoke Mediated ADAM17 Upregulation Can Lead to Impaired Mucociliary Clearance. Cells. 2024 Dec 5;13(23). doi: 10.3390/cells13232009. PubMed PMID: 39682757; PubMed Central PMCID: PMC11640087.

Shaikh SB, Balaya RDA, Dagamajalu S, Bhandary YP, Unwalla H, Prasad TSK, Rahman I. A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence. Cell Commun Signal. 2024 Nov 14;22(1):544. doi: 10.1186/s12964-024-01910-5. Review. PubMed PMID: 39543686; PubMed Central PMCID: PMC11566301.

Rahman MS, Ghorai S, Panda K, Santiago MJ, Aggarwal S, Wang T, Rahman I, Chinnapaiyan S, Unwalla HJ. Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease. Noncoding RNA Res. 2025 Apr;11:22-37. doi: 10.1016/j.ncrna.2024.11.001. eCollection 2025 Apr. Review. PubMed PMID: 39736851; PubMed Central PMCID: PMC11683234.

Nguyen ND, Rosas L, Khaliullin T, Jiang P, Hasanaj E, Ovando-Ricardez JA, Bueno M, Rahman I, Pryhuber GS, Li D, Ma Q, Finkel T, Königshoff M, Eickelberg O, Rojas M, Mora AL, Lugo-Martinez J, Bar-Joseph Z. scDOT: optimal transport for mapping senescent cells in spatial transcriptomics. Genome Biol. 2024 Nov 8;25(1):288. doi: 10.1186/s13059-024-03426-0. PubMed PMID: 39516853; PubMed Central PMCID: PMC11546560.

Kassem NOF, Strongin RM, Stroup AM, Brinkman MC, El-Hellani A, Erythropel HC, Etemadi A, Exil V, Goniewicz ML, Kassem NO, Klupinski TP, Liles S, Muthumalage T, Noël A, Peyton DH, Wang Q, Rahman I, Valerio LG Jr. A Review of the Toxicity of Ingredients in e-Cigarettes, Including Those Ingredients Having the FDA’s “Generally Recognized as Safe (GRAS)” Regulatory Status for Use in Food. Nicotine Tob Res. 2024 Oct 22;26(11):1445-1454. doi: 10.1093/ntr/ntae123. Review. PubMed PMID: 38783714; PubMed Central PMCID: PMC11494494.

Kaur G, Wang Q, Tjitropranoto A, Unwalla H, Rahman I. Cold ischemia time alters cell-type specific senescence leading to loss of cellular integrity in mouse lungs. Exp Lung Res. 2024;50(1):184-198. doi: 10.1080/01902148.2024.2414974. Epub 2024 Oct 20. PubMed PMID: 39427288; PubMed Central PMCID: PMC11513191.

Kassem NOF, Strongin RM, Stroup AM, Brinkman MC, El-Hellani A, Erythropel HC, Etemadi A, Goniewicz ML, Hansen EG, Kassem NO, Li D, Liles S, Noël A, Rezk-Hanna M, Wang Q, Rahman I. Toxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal. Toxicol Sci. 2024 Oct 1;201(2):159-173. doi: 10.1093/toxsci/kfae095. Review. PubMed PMID: 39037923; PubMed Central PMCID: PMC11424890.

Lucas JH, Wang Q, Meehan-Atrash J, Pang C, Rahman I. Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice. Toxicol Sci. 2024 Sep 1;201(1):48-60. doi: 10.1093/toxsci/kfae073. PubMed PMID: 38830033; PubMed Central PMCID: PMC11347778.

Santiago MJ, Chinnapaiyan S, Panda K, Rahman MS, Ghorai S, Lucas JH, Black SM, Rahman I, Unwalla HJ. MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation. J Inflamm (Lond). 2024 Aug 27;21(1):31. doi: 10.1186/s12950-024-00405-x. PubMed PMID: 39192275; PubMed Central PMCID: PMC11348649.

Santiago MJ, Chinnapaiyan S, Panda K, Rahman MS, Ghorai S, Rahman I, Black SM, Liu Y, Unwalla HJ. Altered Host microRNAomics in HIV Infections: Therapeutic Potentials and Limitations. Int J Mol Sci. 2024 Aug 13;25(16). doi: 10.3390/ijms25168809. Review. PubMed PMID: 39201495; PubMed Central PMCID: PMC11354509.

Lucas JH, Wang Q, Pang C, Rahman I. Developmental perfluorooctane sulfonic acid exposure exacerbates house dust mite induced allergic responses in adult mice. Sci Total Environ. 2024 Oct 10;946:173768. doi: 10.1016/j.scitotenv.2024.173768. Epub 2024 Jun 5. PubMed PMID: 38844226; PubMed Central PMCID: PMC11260234.

Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L, Doolittle ML, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. SenNet recommendations for detecting senescent cells in different tissues. Nat Rev Mol Cell Biol. 2024 Dec;25(12):1001-1023. doi: 10.1038/s41580-024-00738-8. Epub 2024 Jun 3. Review. PubMed PMID: 38831121; PubMed Central PMCID: PMC11578798.

Chandy M, Hill T 3rd, Jimenez-Tellez N, Wu JC, Sarles SE, Hensel E, Wang Q, Rahman I, Conklin DJ. Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century: “What Are the Tools Needed for the Job?” and “Do We Have Them?”. Cardiovasc Toxicol. 2024 May;24(5):435-471. doi: 10.1007/s12012-024-09850-9. Epub 2024 Mar 31. Review. PubMed PMID: 38555547; PubMed Central PMCID: PMC11485265.

El-Hellani A, Adeniji A, Erythropel HC, Wang Q, Lamb T, Mikheev VB, Rahman I, Stepanov I, Strongin RM, Wagener TL, Brinkman MC. Comparison of emissions across tobacco products: A slippery slope in tobacco control. Tob Induc Dis. 2024;22. doi: 10.18332/tid/183797. eCollection 2024. Review. PubMed PMID: 38560551; PubMed Central PMCID: PMC10980913.

Kaur G, Sohanur Rahman M, Shaikh S, Panda K, Chinnapaiyan S, Santiago Estevez M, Xia L, Unwalla H, Rahman I. Emerging roles of senolytics/senomorphics in HIV-related co-morbidities. Biochem Pharmacol. 2024 Oct;228:116179. doi: 10.1016/j.bcp.2024.116179. Epub 2024 Mar 29. Review. PubMed PMID: 38556028; PubMed Central PMCID: PMC11410549.

Wang Q, Goracci C, Sundar IK, Rahman I. Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis. J Inflamm (Lond). 2024 Mar 20;21(1):9. doi: 10.1186/s12950-024-00377-y. PubMed PMID: 38509574; PubMed Central PMCID: PMC10956237.

Yehao S, Lamb T, Prabhu P, Li D, McIntosh S, Rahman I. ENDS Tobacco Flavors, Public Health, and Toxicity. [preprint]. 2023 June. doi: 10.20944/preprints202306.0639.v1.

Shaikh SB, Goracci C, Tjitropranoto A, Rahman I. Impact of aging on immune function in the pathogenesis of pulmonary diseases: potential for therapeutic targets. Expert Rev Respir Med. 2023 May;17(5):351-364. doi: 10.1080/17476348.2023.2205127. Epub 2023 Apr 26. Review. PubMed PMID: 37078192; PubMed Central PMCID: PMC10330361.

Kaur G, Muthumalage T, Rahman I. Clearance of senescent cells reverts the cigarette smoke-induced lung senescence and airspace enlargement in p16-3MR mice. Aging Cell. 2023 Jul;22(7):e13850. doi: 10.1111/acel.13850. Epub 2023 Apr 20. PubMed PMID: 37078230; PubMed Central PMCID: PMC10352560.

Sun Y, Newton C, Prabhu P, Dalton A, Robinson D, Li D, McIntosh S, Rahman I. Vaping Greed: Perception, Social Media, Marketing, Public Health, and Toxicity. [preprint]. 2023 April. doi: 10.20944/preprints202304.0073.v1.

Wang Q, Sundar IK, Lucas JH, Park JG, Nogales A, Martinez-Sobrido L, Rahman I. Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization. Nat Commun. 2023 Mar 9;14(1):1295. doi: 10.1038/s41467-023-36896-0. PubMed PMID: 36894533; PubMed Central PMCID: PMC9996598.

Shaikh SB, Newton C, Tung WC, Sun Y, Li D, Ossip D, Rahman I. Classification, Perception, and Toxicity of Emerging Flavored Oral Nicotine Pouches. Int J Environ Res Public Health. 2023 Mar 3;20(5). doi: 10.3390/ijerph20054526. Review. PubMed PMID: 36901533; PubMed Central PMCID: PMC10002198.

Rebuli ME, Rose JJ, Noël A, Croft DP, Benowitz NL, Cohen AH, Goniewicz ML, Larsen BT, Leigh N, McGraw MD, Melzer AC, Penn AL, Rahman I, Upson D, Crotty Alexander LE, Ewart G, Jaspers I, Jordt SE, Kligerman S, Loughlin CE, McConnell R, Neptune ER, Nguyen TB, Pinkerton KE, Witek TJ Jr. The E-cigarette or Vaping Product Use-Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2023 Jan;20(1):1-17. doi: 10.1513/AnnalsATS.202209-796ST. PubMed PMID: 36584985; PubMed Central PMCID: PMC9819258.

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nat Aging. 2022 Dec;2(12):1090-1100. doi: 10.1038/s43587-022-00326-5. Epub 2022 Dec 20. PubMed PMID: 36936385; PubMed Central PMCID: PMC10019484.

Lucas JH, Wang Q, Rahman I. Perfluorooctane Sulfonic Acid Disrupts Protective Tight Junction Proteins via Protein Kinase D in Airway Epithelial Cells. Toxicol Sci. 2022 Nov 23;190(2):215-226. doi: 10.1093/toxsci/kfac096. PubMed PMID: 36106993; PubMed Central PMCID: PMC9960012.

Montuschi P, Rahman I. Editorial: Insights in respiratory pharmacology: 2021. Front Pharmacol. 2022;13:1052994. doi: 10.3389/fphar.2022.1052994. eCollection 2022. PubMed PMID: 36419631; PubMed Central PMCID: PMC9677321.

Shaikh SB, Tung WC, Pang C, Lucas J, Li D, Rahman I. Flavor Classification/Categorization and Differential Toxicity of Oral Nicotine Pouches (ONPs) in Oral Gingival Epithelial Cells and Bronchial Epithelial Cells. Toxics. 2022 Oct 31;10(11). doi: 10.3390/toxics10110660. PubMed PMID: 36355951; PubMed Central PMCID: PMC9696007.

Giri A, Rahman I, Sundar IK. Circadian clock-based therapeutics in chronic pulmonary diseases. Trends Pharmacol Sci. 2022 Dec;43(12):1014-1029. doi: 10.1016/j.tips.2022.09.004. Epub 2022 Oct 24. Review. PubMed PMID: 36302705; PubMed Central PMCID: PMC9756397.

Manevski M, Yogeswaran S, Rahman I, Devadoss D, Chand HS. E-cigarette synthetic cooling agent WS-23 and nicotine aerosols differentially modulate airway epithelial cell responses. Toxicol Rep. 2022;9:1823-1830. doi: 10.1016/j.toxrep.2022.09.010. eCollection 2022. PubMed PMID: 36518432; PubMed Central PMCID: PMC9742947.

Yogeswaran S, Shaikh SB, Manevski M, Chand HS, Rahman I. The role of synthetic coolants, WS-3 and WS-23, in modulating E-cigarette-induced reactive oxygen species (ROS) in lung epithelial cells. Toxicol Rep. 2022;9:1700-1709. doi: 10.1016/j.toxrep.2022.08.007. eCollection 2022. PubMed PMID: 36518479; PubMed Central PMCID: PMC9742959.

Lamb T, Muthumalage T, Meehan-Atrash J, Rahman I. Nose-Only Exposure to Cherry- and Tobacco-Flavored E-Cigarettes Induced Lung Inflammation in Mice in a Sex-Dependent Manner. Toxics. 2022 Aug 13;10(8). doi: 10.3390/toxics10080471. PubMed PMID: 36006150; PubMed Central PMCID: PMC9413458.

Arbat S, Arbat A, Agrawal B, Deshpande P, Rahman I, Bakamwar S, Borkar P. Environmental Exposures and Phenotype of Non-smoking COPD. [preprint]. 2022 June. doi: 10.20944/preprints202206.0334.v1.

Manevski M, Devadoss D, Long C, Singh SP, Nasser MW, Borchert GM, Nair MN, Rahman I, Sopori M, Chand HS. Increased Expression of LASI lncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia. Front Immunol. 2022;13:803362. doi: 10.3389/fimmu.2022.803362. eCollection 2022. PubMed PMID: 35774797; PubMed Central PMCID: PMC9237255.

Michelogiannakis D, Rahman I. Influence of E-Cigarette and Cannabis Vaping on Orthodontically Induced Tooth Movement and Periodontal Health in Patients Undergoing Orthodontic Therapy. Int J Environ Res Public Health. 2022 May 27;19(11). doi: 10.3390/ijerph19116518. PubMed PMID: 35682101; PubMed Central PMCID: PMC9180231.

Giri A, Wang Q, Rahman I, Sundar IK. Circadian molecular clock disruption in chronic pulmonary diseases. Trends Mol Med. 2022 Jun;28(6):513-527. doi: 10.1016/j.molmed.2022.04.002. Epub 2022 May 1. Review. PubMed PMID: 35508604; PubMed Central PMCID: PMC9167664.

Podguski S, Kaur G, Muthumalage T, McGraw MD, Rahman I. Noninvasive systemic biomarkers of e-cigarette or vaping use-associated lung injury: a pilot study. ERJ Open Res. 2022 Apr;8(2). doi: 10.1183/23120541.00639-2021. eCollection 2022 Apr. PubMed PMID: 35386827; PubMed Central PMCID: PMC8977595.

Yogeswaran S, Rahman I. Differences in Acellular Reactive Oxygen Species (ROS) Generation by E-Cigarettes Containing Synthetic Nicotine and Tobacco-Derived Nicotine. Toxics. 2022 Mar 11;10(3). doi: 10.3390/toxics10030134. PubMed PMID: 35324759; PubMed Central PMCID: PMC8951519.

McGraw MD, Croft DP, Nacca NE, Rahman I. Reduced plasma phosphatidylethanolamines in e-cigarette, or vaping, product use-associated lung injury (EVALI). Pediatr Pulmonol. 2022 May;57(5):1350-1354. doi: 10.1002/ppul.25874. Epub 2022 Mar 9. PubMed PMID: 35233972; PubMed Central PMCID: PMC9615110.

Wang Q, Unwalla H, Rahman I. Dysregulation of mitochondrial complexes and dynamics by chronic cigarette smoke exposure Utilizing MitoQC reporter mice. Mitochondrion. 2022 Mar;63:43-50. doi: 10.1016/j.mito.2022.01.003. Epub 2022 Jan 13. PubMed PMID: 35032706; PubMed Central PMCID: PMC8885972.

Meehan-Atrash J, Rahman I. Novel Δ(8)-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals. Chem Res Toxicol. 2022 Jan 17;35(1):73-76. doi: 10.1021/acs.chemrestox.1c00388. Epub 2021 Dec 10. PubMed PMID: 34889611; PubMed Central PMCID: PMC8898185.

Le HHT, Liu CW, Denaro P 3rd, Jousma J, Shao NY, Rahman I, Lee WH. Genome-wide differential expression profiling of lncRNAs and mRNAs in human induced pluripotent stem cell-derived endothelial cells exposed to e-cigarette extract. Stem Cell Res Ther. 2021 Dec 4;12(1):593. doi: 10.1186/s13287-021-02654-6. PubMed PMID: 34863290; PubMed Central PMCID: PMC8643021.

Sharma S, Wang Q, Muthumalage T, Rahman I. Epithelial Ablation of Miro1/Rhot1 GTPase Augments Lung Inflammation by Cigarette Smoke. Pathophysiology. 2021 Nov 26;28(4):501-512. doi: 10.3390/pathophysiology28040033. PubMed PMID: 35366248; PubMed Central PMCID: PMC8830451.

Kaur G, Maremanda KP, Campos M, Chand HS, Li F, Hirani N, Haseeb MA, Li D, Rahman I. Distinct Exosomal miRNA Profiles from BALF and Lung Tissue of COPD and IPF Patients. Int J Mol Sci. 2021 Oct 31;22(21). doi: 10.3390/ijms222111830. PubMed PMID: 34769265; PubMed Central PMCID: PMC8584050.

Meehan-Atrash J, Rahman I. Cannabis Vaping: Existing and Emerging Modalities, Chemistry, and Pulmonary Toxicology. Chem Res Toxicol. 2021 Oct 18;34(10):2169-2179. doi: 10.1021/acs.chemrestox.1c00290. Epub 2021 Oct 8. PubMed PMID: 34622654; PubMed Central PMCID: PMC8882064.

Kaur G, Ji X, Rahman I. SARS-CoV2 Infection Alters Tryptophan Catabolism and Phospholipid Metabolism. Metabolites. 2021 Sep 28;11(10). doi: 10.3390/metabo11100659. PubMed PMID: 34677374; PubMed Central PMCID: PMC8538244.

Yogeswaran S, Muthumalage T, Rahman I. Comparative Reactive Oxygen Species (ROS) Content among Various Flavored Disposable Vape Bars, including Cool (Iced) Flavored Bars. Toxics. 2021 Sep 25;9(10). doi: 10.3390/toxics9100235. PubMed PMID: 34678931; PubMed Central PMCID: PMC8538728.

Polverino F, Wu TD, Rojas-Quintero J, Wang X, Mayo J, Tomchaney M, Tram J, Packard S, Zhang D, Cleveland KH, Cordoba-Lanus E, Owen CA, Fawzy A, Kinney GL, Hersh CP, Hansel NN, Doubleday K, Sauler M, Tesfaigzi Y, Ledford JG, Casanova C, Zmijewski J, Konhilas J, Langlais PR, Schnellmann R, Rahman I, McCormack M, Celli B. Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. Am J Respir Crit Care Med. 2021 Sep 15;204(6):651-666. doi: 10.1164/rccm.202012-4510OC. PubMed PMID: 34033525; PubMed Central PMCID: PMC8521702.

Dutta RK, Chinnapaiyan S, Santiago MJ, Rahman I, Unwalla HJ. Gene-specific MicroRNA antagonism protects against HIV Tat and TGF-β-mediated suppression of CFTR mRNA and function. Biomed Pharmacother. 2021 Oct;142:112090. doi: 10.1016/j.biopha.2021.112090. Epub 2021 Aug 27. PubMed PMID: 34463266; PubMed Central PMCID: PMC9100877.

Kaur G, Maremanda K, Campos M, Chand H, Li F, Hirani N, Haseeb M, Rahman I. Distinct Exosomal miRNA Profiles from BALF and Lung Tissue from COPD and IPF Patients. [preprint]. 2021 August. doi: 10.20944/preprints202108.0520.v1.

Maremanda KP, Sundar IK, Rahman I. Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD. Redox Biol. 2021 Sep;45:102055. doi: 10.1016/j.redox.2021.102055. Epub 2021 Jun 24. PubMed PMID: 34214709; PubMed Central PMCID: PMC8258692.

Wang Q, Sundar IK, Lucas JH, Muthumalage T, Rahman I. Molecular clock REV-ERBα regulates cigarette smoke-induced pulmonary inflammation and epithelial-mesenchymal transition. JCI Insight. 2021 Jun 22;6(12). doi: 10.1172/jci.insight.145200. PubMed PMID: 34014841; PubMed Central PMCID: PMC8262497.

Lucas JH, Wang Q, Muthumalage T, Rahman I. Multi-Walled Carbon Nanotubes (MWCNTs) Cause Cellular Senescence in TGF-β Stimulated Lung Epithelial Cells. Toxics. 2021 Jun 19;9(6). doi: 10.3390/toxics9060144. PubMed PMID: 34205339; PubMed Central PMCID: PMC8234672.

Bhat TA, Kalathil SG, Leigh N, Muthumalage T, Rahman I, Goniewicz ML, Thanavala YM. Acute Effects of Heated Tobacco Product (IQOS) Aerosol Inhalation on Lung Tissue Damage and Inflammatory Changes in the Lungs. Nicotine Tob Res. 2021 Jun 8;23(7):1160-1167. doi: 10.1093/ntr/ntaa267. PubMed PMID: 33346355; PubMed Central PMCID: PMC8186425.

Wang Q, Ji X, Rahman I. Dysregulated Metabolites Serve as Novel Biomarkers for Metabolic Diseases Caused by E-Cigarette Vaping and Cigarette Smoking. Metabolites. 2021 May 29;11(6). doi: 10.3390/metabo11060345. PubMed PMID: 34072305; PubMed Central PMCID: PMC8229291.

Kaur G, Yogeswaran S, Muthumalage T, Rahman I. Persistently Increased Systemic ACE2 Activity Is Associated With an Increased Inflammatory Response in Smokers With COVID-19. Front Physiol. 2021;12:653045. doi: 10.3389/fphys.2021.653045. eCollection 2021. PubMed PMID: 34122129; PubMed Central PMCID: PMC8194708.

Kaur G, Sundar IK, Rahman I. p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries. Int J Mol Sci. 2021 May 3;22(9). doi: 10.3390/ijms22094834. PubMed PMID: 34063608; PubMed Central PMCID: PMC8125702.

Xie Z, Rahman I, Goniewicz ML, Li D. Perspectives on Epigenetics Alterations Associated with Smoking and Vaping. Function (Oxf). 2021;2(3):zqab022. doi: 10.1093/function/zqab022. eCollection 2021. Review. PubMed PMID: 35330676; PubMed Central PMCID: PMC8788872.

Tarran R, Barr RG, Benowitz NL, Bhatnagar A, Chu HW, Dalton P, Doerschuk CM, Drummond MB, Gold DR, Goniewicz ML, Gross ER, Hansel NN, Hopke PK, Kloner RA, Mikheev VB, Neczypor EW, Pinkerton KE, Postow L, Rahman I, Samet JM, Salathe M, Stoney CM, Tsao PS, Widome R, Xia T, Xiao D, Wold LE. E-Cigarettes and Cardiopulmonary Health. Function (Oxf). 2021;2(2):zqab004. doi: 10.1093/function/zqab004. eCollection 2021. Review. PubMed PMID: 33748758; PubMed Central PMCID: PMC7948134.

McDonough SR, Rahman I, Sundar IK. Recent updates on biomarkers of exposure and systemic toxicity in e-cigarette users and EVALI. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L661-L679. doi: 10.1152/ajplung.00520.2020. Epub 2021 Jan 27. Review. PubMed PMID: 33501893; PubMed Central PMCID: PMC8174828.

Quinones Tavarez Z, Li D, Croft DP, Gill SR, Ossip DJ, Rahman I. The Interplay Between Respiratory Microbiota and Innate Immunity in Flavor E-Cigarette Vaping Induced Lung Dysfunction. Front Microbiol. 2020;11:589501. doi: 10.3389/fmicb.2020.589501. eCollection 2020. Review. PubMed PMID: 33391205; PubMed Central PMCID: PMC7772214.

Schneller LM, Quiñones Tavárez Z, Goniewicz ML, Xie Z, McIntosh S, Rahman I, O’Connor RJ, Ossip DJ, Li D. Cross-Sectional Association Between Exclusive and Concurrent Use of Cigarettes, ENDS, and Cigars, the Three Most Popular Tobacco Products, and Wheezing Symptoms Among U.S. Adults. Nicotine Tob Res. 2020 Dec 15;22(Suppl 1):S76-S84. doi: 10.1093/ntr/ntaa199. PubMed PMID: 33320256; PubMed Central PMCID: PMC8224835.

Kaur G, Singh K, Maremanda KP, Li D, Chand HS, Rahman I. Differential plasma exosomal long non-coding RNAs expression profiles and their emerging role in E-cigarette users, cigarette, waterpipe, and dual smokers. PLoS One. 2020;15(12):e0243065. doi: 10.1371/journal.pone.0243065. eCollection 2020. PubMed PMID: 33290406; PubMed Central PMCID: PMC7723270.

Wang Q, Sundar IK, Blum JL, Ratner JR, Lucas JH, Chuang TD, Wang Y, Liu J, Rehan VK, Zelikoff JT, Rahman I. Prenatal Exposure to Electronic-Cigarette Aerosols Leads to Sex-Dependent Pulmonary Extracellular-Matrix Remodeling and Myogenesis in Offspring Mice. Am J Respir Cell Mol Biol. 2020 Dec;63(6):794-805. doi: 10.1165/rcmb.2020-0036OC. PubMed PMID: 32853043; PubMed Central PMCID: PMC7790147.

Kaur G, Gaurav A, Lamb T, Perkins M, Muthumalage T, Rahman I. Current Perspectives on Characteristics, Compositions, and Toxicological Effects of E-Cigarettes Containing Tobacco and Menthol/Mint Flavors. Front Physiol. 2020;11:613948. doi: 10.3389/fphys.2020.613948. eCollection 2020. Review. PubMed PMID: 33329065; PubMed Central PMCID: PMC7710937.

Xie Z, Ossip DJ, Rahman I, O’Connor RJ, Li D. Electronic cigarette use and subjective cognitive complaints in adults. PLoS One. 2020;15(11):e0241599. doi: 10.1371/journal.pone.0241599. eCollection 2020. PubMed PMID: 33137145; PubMed Central PMCID: PMC7605645.

Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest. 2020 Nov 2;130(11):6189. doi: 10.1172/JCI143863. PubMed PMID: 33136096; PubMed Central PMCID: PMC7598037.

Alderawi A, Caramori G, Baker EH, Hitchings AW, Rahman I, Rossios C, Adcock I, Cassolari P, Papi A, Ortega VE, Curtis JL, Dunmore S, Kirkham P. FN3K expression in COPD: a potential comorbidity factor for cardiovascular disease. BMJ Open Respir Res. 2020 Nov;7(1). doi: 10.1136/bmjresp-2020-000714. PubMed PMID: 33208304; PubMed Central PMCID: PMC7677354.

Shi H, Tavárez ZQ, Xie Z, Schneller LM, Croft DP, Goniewicz ML, McIntosh S, O’Connor RJ, Ossip DJ, Rahman I, Li D. Association of flavored electronic nicotine delivery system (ENDS) use with self-reported chronic obstructive pulmonary disease (COPD): Results from the Population Assessment of Tobacco and Health (PATH) study, Wave 4. Tob Induc Dis. 2020;18:82. doi: 10.18332/tid/127238. eCollection 2020. PubMed PMID: 33082739; PubMed Central PMCID: PMC7549379.

Singh KP, Maremanda KP, Li D, Rahman I. Exosomal microRNAs are novel circulating biomarkers in cigarette, waterpipe smokers, E-cigarette users and dual smokers. BMC Med Genomics. 2020 Sep 10;13(1):128. doi: 10.1186/s12920-020-00748-3. PubMed PMID: 32912198; PubMed Central PMCID: PMC7488025.

Maremanda KP, Sundar IK, Li D, Rahman I. Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. Front Pharmacol. 2020;11:584637. doi: 10.3389/fphar.2020.584637. eCollection 2020. PubMed PMID: 33013423; PubMed Central PMCID: PMC7510459.

Lucas JH, Muthumalage T, Wang Q, Friedman MR, Friedman AE, Rahman I. E-Liquid Containing a Mixture of Coconut, Vanilla, and Cookie Flavors Causes Cellular Senescence and Dysregulated Repair in Pulmonary Fibroblasts: Implications on Premature Aging. Front Physiol. 2020;11:924. doi: 10.3389/fphys.2020.00924. eCollection 2020. PubMed PMID: 33013432; PubMed Central PMCID: PMC7500211.

Schneller LM, Li D, Tavárez ZQ, Goniewicz ML, Quisenberry AJ, Xie Z, Rahman I, McIntosh S, O’Connor RJ, Ossip DJ. Flavor Inconsistencies between Flavored Tobacco Products among US Adults. Am J Health Behav. 2020 Sep 1;44(5):617-630. doi: 10.5993/AJHB.44.5.6. PubMed PMID: 33121580; PubMed Central PMCID: PMC7751059.

Lamb T, Muthumalage T, Rahman I. Pod-based menthol and tobacco flavored e-cigarettes cause mitochondrial dysfunction in lung epithelial cells. Toxicol Lett. 2020 Oct 15;333:303-311. doi: 10.1016/j.toxlet.2020.08.003. Epub 2020 Aug 9. PubMed PMID: 32783911; PubMed Central PMCID: PMC7578111.

Fong G, Gayen Nee’ Betal S, Murthy S, Favara M, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Li D, Rahman I, Aghai ZH. DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis. Front Pediatr. 2020;8:437. doi: 10.3389/fped.2020.00437. eCollection 2020. PubMed PMID: 32850550; PubMed Central PMCID: PMC7417608.

Li D, Shi H, Xie Z, Rahman I, McIntosh S, Bansal-Travers M, Winickoff JP, Drehmer JE, Ossip DJ. Home smoking and vaping policies among US adults: results from the Population Assessment of Tobacco and Health (PATH) study, wave 3. Prev Med. 2020 Oct;139:106215. doi: 10.1016/j.ypmed.2020.106215. Epub 2020 Jul 18. PubMed PMID: 32693178; PubMed Central PMCID: PMC7494576.

Muthumalage T, Lucas JH, Wang Q, Lamb T, McGraw MD, Rahman I. Pulmonary Toxicity and Inflammatory Response of E-Cigarette Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI. Toxics. 2020 Jun 28;8(3). doi: 10.3390/toxics8030046. PubMed PMID: 32605182; PubMed Central PMCID: PMC7560420.

Wang Q, Sundar IK, Li D, Lucas JH, Muthumalage T, McDonough SR, Rahman I. E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation. Respir Res. 2020 Jun 18;21(1):154. doi: 10.1186/s12931-020-01396-y. PubMed PMID: 32552811; PubMed Central PMCID: PMC7301079.

Maremanda KP, Sundar IK, Li D, Rahman I. Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis. Res Sq. 2020 Jun 15;. doi: 10.21203/rs.3.rs-35347/v1. PubMed PMID: 32702724; PubMed Central PMCID: PMC7336702.

Xie Z, Ossip DJ, Rahman I, Li D. Use of Electronic Cigarettes and Self-Reported Chronic Obstructive Pulmonary Disease Diagnosis in Adults. Nicotine Tob Res. 2020 Jun 12;22(7):1155-1161. doi: 10.1093/ntr/ntz234. PubMed PMID: 31830263; PubMed Central PMCID: PMC7291797.

Kaur G, Lungarella G, Rahman I. SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping. J Inflamm (Lond). 2020;17:21. doi: 10.1186/s12950-020-00250-8. eCollection 2020. Review. PubMed PMID: 32528233; PubMed Central PMCID: PMC7284674.

Wang Q, Sundar I, Li D, Lucas J, Muthumalage T, McDonough S, Rahman I. E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR α7 Receptor: Role of nAChR α7 in ACE2 Covid-19 receptor regulation. Res Sq. 2020 May 18;. doi: 10.21203/rs.2.23829/v2. PubMed PMID: 32702718; PubMed Central PMCID: PMC7336696.

Chinnapaiyan S, Dutta RK, Devadoss D, Chand HS, Rahman I, Unwalla HJ. Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases. Int J Mol Sci. 2020 Apr 24;21(8). doi: 10.3390/ijms21083013. Review. PubMed PMID: 32344623; PubMed Central PMCID: PMC7215637.

Muthumalage T, Friedman MR, McGraw MD, Ginsberg G, Friedman AE, Rahman I. Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI). Toxics. 2020 Apr 3;8(2). doi: 10.3390/toxics8020025. PubMed PMID: 32260052; PubMed Central PMCID: PMC7355865.

Ye D, Gajendra S, Lawyer G, Jadeja N, Pishey D, Pathagunti S, Lyons J, Veazie P, Watson G, McIntosh S, Rahman I. Inflammatory biomarkers and growth factors in saliva and gingival crevicular fluid of e-cigarette users, cigarette smokers, and dual smokers: A pilot study. J Periodontol. 2020 Oct;91(10):1274-1283. doi: 10.1002/JPER.19-0457. Epub 2020 Mar 16. PubMed PMID: 32052441; PubMed Central PMCID: PMC9014419.

McGraw MD, Kim SY, Reed C, Hernady E, Rahman I, Mariani TJ, Finkelstein JN. Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure. Toxicol Lett. 2020 Jun 1;325:25-33. doi: 10.1016/j.toxlet.2020.02.012. Epub 2020 Feb 26. PubMed PMID: 32112875; PubMed Central PMCID: PMC7164319.

Manevski M, Muthumalage T, Devadoss D, Sundar IK, Wang Q, Singh KP, Unwalla HJ, Chand HS, Rahman I. Cellular stress responses and dysfunctional Mitochondrial-cellular senescence, and therapeutics in chronic respiratory diseases. Redox Biol. 2020 Jun;33:101443. doi: 10.1016/j.redox.2020.101443. Epub 2020 Jan 25. Review. PubMed PMID: 32037306; PubMed Central PMCID: PMC7251248.

Jackson M, Singh KP, Lamb T, McIntosh S, Rahman I. Flavor Preference and Systemic Immunoglobulin Responses in E-Cigarette Users and Waterpipe and Tobacco Smokers: A Pilot Study. Int J Environ Res Public Health. 2020 Jan 19;17(2). doi: 10.3390/ijerph17020640. PubMed PMID: 31963835; PubMed Central PMCID: PMC7013586.

Chand HS, Muthumalage T, Maziak W, Rahman I. Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury. Front Pharmacol. 2019;10:1619. doi: 10.3389/fphar.2019.01619. eCollection 2019. PubMed PMID: 31992985; PubMed Central PMCID: PMC6971159.

Muthumalage T, Lamb T, Friedman MR, Rahman I. E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes. Sci Rep. 2019 Dec 13;9(1):19035. doi: 10.1038/s41598-019-51643-6. PubMed PMID: 31836726; PubMed Central PMCID: PMC6910911.

Lawyer GR, Jackson M, Prinz M, Lamb T, Wang Q, Muthumalage T, Rahman I. Classification of flavors in cigarillos and little cigars and their variable cellular and acellular oxidative and cytotoxic responses. PLoS One. 2019;14(12):e0226066. doi: 10.1371/journal.pone.0226066. eCollection 2019. PubMed PMID: 31825984; PubMed Central PMCID: PMC6905550.

Devadoss D, Long C, Langley RJ, Manevski M, Nair M, Campos MA, Borchert G, Rahman I, Chand HS. Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2019 Dec;61(6):678-688. doi: 10.1165/rcmb.2019-0184TR. Review. PubMed PMID: 31486667; PubMed Central PMCID: PMC6890411.

Sundar IK, Li D, Rahman I. Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers. J Extracell Vesicles. 2019;8(1):1684816. doi: 10.1080/20013078.2019.1684816. eCollection 2019. PubMed PMID: 31762962; PubMed Central PMCID: PMC6848892.

Maremanda KP, Sundar IK, Rahman I. Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. Toxicol Appl Pharmacol. 2019 Dec 15;385:114788. doi: 10.1016/j.taap.2019.114788. Epub 2019 Oct 31. PubMed PMID: 31678243; PubMed Central PMCID: PMC6894395.

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Sundar IK, Maremanda KP, Rahman I. Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke. Toxicol Lett. 2019 Dec 15;317:92-101. doi: 10.1016/j.toxlet.2019.09.022. Epub 2019 Oct 5. PubMed PMID: 31593750; PubMed Central PMCID: PMC6935378.

Singh KP, Lawyer G, Muthumalage T, Maremanda KP, Khan NA, McDonough SR, Ye D, McIntosh S, Rahman I. Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries. ERJ Open Res. 2019 Oct;5(4). doi: 10.1183/23120541.00182-2019. eCollection 2019 Oct. PubMed PMID: 31886159; PubMed Central PMCID: PMC6926365.

Javed F, Rahman I, Romanos GE. Tobacco-product usage as a risk factor for dental implants. Periodontol 2000. 2019 Oct;81(1):48-56. doi: 10.1111/prd.12282. Review. PubMed PMID: 31407428.

Khan NA, Lawyer G, McDonough S, Wang Q, Kassem NO, Kas-Petrus F, Ye D, Singh KP, Kassem NO, Rahman I. Systemic biomarkers of inflammation, oxidative stress and tissue injury and repair among waterpipe, cigarette and dual tobacco smokers. Tob Control. 2020 Feb;29(Suppl 2):s102-s109. doi: 10.1136/tobaccocontrol-2019-054958. Epub 2019 Sep 7. PubMed PMID: 31494573; PubMed Central PMCID: PMC7050420.

Chinnapaiyan S, Dutta RK, Nair M, Chand HS, Rahman I, Unwalla HJ. TGF-β1 increases viral burden and promotes HIV-1 latency in primary differentiated human bronchial epithelial cells. Sci Rep. 2019 Aug 29;9(1):12552. doi: 10.1038/s41598-019-49056-6. PubMed PMID: 31467373; PubMed Central PMCID: PMC6715689.

Wang Q, Khan NA, Muthumalage T, Lawyer GR, McDonough SR, Chuang TD, Gong M, Sundar IK, Rehan VK, Rahman I. Dysregulated repair and inflammatory responses by e-cigarette-derived inhaled nicotine and humectant propylene glycol in a sex-dependent manner in mouse lung. FASEB Bioadv. 2019 Oct;1(10):609-623. doi: 10.1096/fba.2019-00048. Epub 2019 Aug 23. PubMed PMID: 31825014; PubMed Central PMCID: PMC6902908.

Muthumalage T, Rahman I. Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts. Toxicol Appl Pharmacol. 2019 Nov 1;382:114713. doi: 10.1016/j.taap.2019.114713. Epub 2019 Aug 19. PubMed PMID: 31437494; PubMed Central PMCID: PMC6917034.

BinShabaib M, ALHarthi SS, Akram Z, Khan J, Rahman I, Romanos GE, Javed F. Clinical periodontal status and gingival crevicular fluid cytokine profile among cigarette-smokers, electronic-cigarette users and never-smokers. Arch Oral Biol. 2019 Jun;102:212-217. doi: 10.1016/j.archoralbio.2019.05.001. Epub 2019 May 3. PubMed PMID: 31078071.

Gayen Nee’ Betal S, Murthy S, Favara M, Fong G, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Rahman I, Aghai ZH. Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates. Sci Rep. 2019 Apr 10;9(1):5862. doi: 10.1038/s41598-019-42205-x. PubMed PMID: 30971730; PubMed Central PMCID: PMC6458165.

Khan NA, Yogeswaran S, Wang Q, Muthumalage T, Sundar IK, Rahman I. Waterpipe smoke and e-cigarette vapor differentially affect circadian molecular clock gene expression in mouse lungs. PLoS One. 2019;14(2):e0211645. doi: 10.1371/journal.pone.0211645. eCollection 2019. PubMed PMID: 30811401; PubMed Central PMCID: PMC6392409.

Li D, Sundar IK, McIntosh S, Ossip DJ, Goniewicz ML, O’Connor RJ, Rahman I. Association of smoking and electronic cigarette use with wheezing and related respiratory symptoms in adults: cross-sectional results from the Population Assessment of Tobacco and Health (PATH) study, wave 2. Tob Control. 2020 Mar;29(2):140-147. doi: 10.1136/tobaccocontrol-2018-054694. Epub 2019 Feb 13. PubMed PMID: 30760629; PubMed Central PMCID: PMC6692241.

ALHarthi SS, BinShabaib M, Akram Z, Rahman I, Romanos GE, Javed F. Impact of cigarette smoking and vaping on the outcome of full-mouth ultrasonic scaling among patients with gingival inflammation: a prospective study. Clin Oral Investig. 2019 Jun;23(6):2751-2758. doi: 10.1007/s00784-018-2725-2. Epub 2018 Oct 26. PubMed PMID: 30361795.

Schneller LM, McIntosh S, Li D, Rahman I, Ossip D, Goniewicz M, O’Connor RJ. Tobacco use and chemosensory impairments among current adult tobacco users in the US: Data from NHANES 2013-2014. Tob Induc Dis. 2018;16:43. doi: 10.18332/tid/94202. eCollection 2018. PubMed PMID: 31516441; PubMed Central PMCID: PMC6659548.

Sundar IK, Rashid K, Gerloff J, Li D, Rahman I. Genetic Ablation of p16(INK4a) Does Not Protect against Cellular Senescence in Mouse Models of Chronic Obstructive Pulmonary Disease/Emphysema. Am J Respir Cell Mol Biol. 2018 Aug;59(2):189-199. doi: 10.1165/rcmb.2017-0390OC. PubMed PMID: 29447461; PubMed Central PMCID: PMC6096345.

Lee H, Lee J, Hong SH, Rahman I, Yang SR. Inhibition of RAGE Attenuates Cigarette Smoke-Induced Lung Epithelial Cell Damage via RAGE-Mediated Nrf2/DAMP Signaling. Front Pharmacol. 2018;9:684. doi: 10.3389/fphar.2018.00684. eCollection 2018. PubMed PMID: 30013476; PubMed Central PMCID: PMC6036614.

Rashid K, Sundar IK, Gerloff J, Li D, Rahman I. Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema. Sci Rep. 2018 Jun 13;8(1):9023. doi: 10.1038/s41598-018-27209-3. PubMed PMID: 29899396; PubMed Central PMCID: PMC5998122.

Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM. Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice. Sci Rep. 2018 Apr 10;8(1):5746. doi: 10.1038/s41598-018-24166-9. PubMed PMID: 29636532; PubMed Central PMCID: PMC5893541.

Sundar IK, Rashid K, Gerloff J, Rangel-Moreno J, Li D, Rahman I. Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema. FASEB J. 2018 Sep;32(9):4955-4971. doi: 10.1096/fj.201701518R. Epub 2018 Apr 9. PubMed PMID: 29630406; PubMed Central PMCID: PMC6103175.

Eddingsaas N, Pagano T, Cummings C, Rahman I, Robinson R, Hensel E. Qualitative Analysis of E-Liquid Emissions as a Function of Flavor Additives Using Two Aerosol Capture Methods. Int J Environ Res Public Health. 2018 Feb 13;15(2). doi: 10.3390/ijerph15020323. PubMed PMID: 29438289; PubMed Central PMCID: PMC5858392.

Khan NA, Sundar IK, Rahman I. Strain- and sex-dependent pulmonary toxicity of waterpipe smoke in mouse. Physiol Rep. 2018 Feb;6(3). doi: 10.14814/phy2.13579. PubMed PMID: 29417753; PubMed Central PMCID: PMC5803106.

Muthumalage T, Prinz M, Ansah KO, Gerloff J, Sundar IK, Rahman I. Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine. Front Physiol. 2017;8:1130. doi: 10.3389/fphys.2017.01130. eCollection 2017. PubMed PMID: 29375399; PubMed Central PMCID: PMC5768608.

Tang M, Ji C, Pallo S, Rahman I, Johnson GVW. Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner. Neurobiol Aging. 2018 Mar;63:128-139. doi: 10.1016/j.neurobiolaging.2017.12.001. Epub 2017 Dec 9. PubMed PMID: 29304346; PubMed Central PMCID: PMC5801049.

Javed F, Kellesarian SV, Abduljabbar T, Abduljabbar AT, Akram Z, Vohra F, Rahman I, Romanos GE. Influence of involuntary cigarette smoke inhalation on osseointegration: a systematic review and meta-analysis of preclinical studies. Int J Oral Maxillofac Surg. 2018 Jun;47(6):764-772. doi: 10.1016/j.ijom.2017.11.009. Epub 2017 Dec 9. PubMed PMID: 29233582.

Sundar IK, Sellix MT, Rahman I. Redox regulation of circadian molecular clock in chronic airway diseases. Free Radic Biol Med. 2018 May 1;119:121-128. doi: 10.1016/j.freeradbiomed.2017.10.383. Epub 2017 Oct 31. Review. PubMed PMID: 29097215; PubMed Central PMCID: PMC5910271.

Sundar IK, Rashid K, Sellix MT, Rahman I. The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation. Biochem Biophys Res Commun. 2017 Dec 2;493(4):1390-1395. doi: 10.1016/j.bbrc.2017.09.157. Epub 2017 Sep 30. PubMed PMID: 28974420; PubMed Central PMCID: PMC5756581.

Rahman I, De Cunto G, Sundar IK, Lungarella G. Vulnerability and Genetic Susceptibility to Cigarette Smoke-Induced Emphysema in Mice. Am J Respir Cell Mol Biol. 2017 Sep;57(3):270-271. doi: 10.1165/rcmb.2017-0175ED. PubMed PMID: 28862508; PubMed Central PMCID: PMC5625231.

Javed F, ALHarthi SS, BinShabaib MS, Gajendra S, Romanos GE, Rahman I. Toxicological impact of waterpipe smoking and flavorings in the oral cavity and respiratory system. Inhal Toxicol. 2017 Aug;29(9):389-396. doi: 10.1080/08958378.2017.1384084. Epub 2017 Oct 17. Review. PubMed PMID: 29039225; PubMed Central PMCID: PMC5927775.

Behrsing H, Hill E, Raabe H, Tice R, Fitzpatrick S, Devlin R, Pinkerton K, Oberdörster G, Wright C, Wieczorek R, Aufderheide M, Steiner S, Krebs T, Asgharian B, Corley R, Oldham M, Adamson J, Li X, Rahman I, Grego S, Chu PH, McCullough S, Curren R. In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use. Altern Lab Anim. 2017 Jul;45(3):117-158. doi: 10.1177/026119291704500305. PubMed PMID: 28816053; PubMed Central PMCID: PMC9878375.

Snow E, Johnson T, Ossip DJ, Williams GC, Ververs D, Rahman I, McIntosh S. Does E-cigarette Use at Baseline Influence Smoking Cessation Rates among 2-Year College Students?. J Smok Cessat. 2018 Jun;13(2):110-120. doi: 10.1017/jsc.2017.11. Epub 2017 Jun 28. PubMed PMID: 30034554; PubMed Central PMCID: PMC6051717.

Javed F, Abduljabbar T, Vohra F, Malmstrom H, Rahman I, Romanos GE. Comparison of Periodontal Parameters and Self-Perceived Oral Symptoms Among Cigarette Smokers, Individuals Vaping Electronic Cigarettes, and Never-Smokers. J Periodontol. 2017 Oct;88(10):1059-1065. doi: 10.1902/jop.2017.170197. Epub 2017 Jun 23. PubMed PMID: 28644108.

Sundar IK, Yin Q, Baier BS, Yan L, Mazur W, Li D, Susiarjo M, Rahman I. DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. Clin Epigenetics. 2017;9:38. doi: 10.1186/s13148-017-0335-5. eCollection 2017. PubMed PMID: 28416970; PubMed Central PMCID: PMC5391602.

Javed F, Kellesarian SV, Sundar IK, Romanos GE, Rahman I. Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues. Oral Dis. 2017 Nov;23(8):1052-1057. doi: 10.1111/odi.12652. Epub 2017 Mar 30. Review. PubMed PMID: 28168771; PubMed Central PMCID: PMC5545167.

Lei W, Lerner C, Sundar IK, Rahman I. Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III. Sci Rep. 2017 Mar 3;7:43213. doi: 10.1038/srep43213. PubMed PMID: 28256533; PubMed Central PMCID: PMC5335673.

Gerloff J, Sundar IK, Freter R, Sekera ER, Friedman AE, Robinson R, Pagano T, Rahman I. Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts. Appl In Vitro Toxicol. 2017 Mar 1;3(1):28-40. doi: 10.1089/aivt.2016.0030. PubMed PMID: 28337465; PubMed Central PMCID: PMC5338075.

Arbat S, Dave M, Niranjane V, Rahman I, Arbat A. Analyzing the clinical profile of swine flu/influenza A H1N1 infection in central India: a retrospective study. Virusdisease. 2017 Mar;28(1):33-38. doi: 10.1007/s13337-017-0363-y. Epub 2017 Mar 18. PubMed PMID: 28466053; PubMed Central PMCID: PMC5377859.

Lee H, Park JR, Kim WJ, Sundar IK, Rahman I, Park SM, Yang SR. Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling. FASEB J. 2017 May;31(5):2076-2089. doi: 10.1096/fj.201601155R. Epub 2017 Feb 1. PubMed PMID: 28148566; PubMed Central PMCID: PMC5388549.

Ahmad T, Sundar IK, Tormos AM, Lerner CA, Gerloff J, Yao H, Rahman I. Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2017 Jan;56(1):38-49. doi: 10.1165/rcmb.2016-0198OC. PubMed PMID: 27559927; PubMed Central PMCID: PMC5248966.

Sundar IK, Javed F, Romanos GE, Rahman I. E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts. Oncotarget. 2016 Nov 22;7(47):77196-77204. doi: 10.18632/oncotarget.12857. PubMed PMID: 27791204; PubMed Central PMCID: PMC5363580.

Valacchi G, Cervellati C, Evelson P, Rahman I. Redox regulation of inflammatory processes. Int J Biochem Cell Biol. 2016 Dec;81(Pt B):234-235. doi: 10.1016/j.biocel.2016.11.002. Epub 2016 Nov 3. PubMed PMID: 27818335.

Sundar IK, Rahman I. Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1245-L1258. doi: 10.1152/ajplung.00253.2016. Epub 2016 Oct 28. PubMed PMID: 27793800; PubMed Central PMCID: PMC5206398.

Lerner CA, Lei W, Sundar IK, Rahman I. Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury. Front Pharmacol. 2016;7:391. doi: 10.3389/fphar.2016.00391. eCollection 2016. PubMed PMID: 27826243; PubMed Central PMCID: PMC5078490.

Lerner CA, Sundar IK, Rahman I. Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD. Int J Biochem Cell Biol. 2016 Dec;81(Pt B):294-306. doi: 10.1016/j.biocel.2016.07.026. Epub 2016 Jul 26. Review. PubMed PMID: 27474491; PubMed Central PMCID: PMC5154857.

Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I. Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts. Biochem Biophys Res Commun. 2016 Sep 2;477(4):620-625. doi: 10.1016/j.bbrc.2016.06.109. Epub 2016 Jun 23. PubMed PMID: 27343559; PubMed Central PMCID: PMC4967027.

Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I. Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2015 Dec;53(6):782-92. doi: 10.1165/rcmb.2014-0474OC. PubMed PMID: 25905433; PubMed Central PMCID: PMC4742939.

Javed F, Al-Kheraif AA, Rahman I, Millan-Luongo LT, Feng C, Yunker M, Malmstrom H, Romanos GE. Comparison of Clinical and Radiographic Periodontal Status Between Habitual Water-Pipe Smokers and Cigarette Smokers. J Periodontol. 2016 Feb;87(2):142-7. doi: 10.1902/jop.2015.150235. Epub 2015 Oct 2. PubMed PMID: 26430928.

Sundar IK, Yao H, Sellix MT, Rahman I. Circadian molecular clock in lung pathophysiology. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1056-75. doi: 10.1152/ajplung.00152.2015. Epub 2015 Sep 11. Review. PubMed PMID: 26361874; PubMed Central PMCID: PMC4652147.

Sundar IK, Yao H, Sellix MT, Rahman I. Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases. Am J Respir Cell Mol Biol. 2015 Sep;53(3):285-90. doi: 10.1165/rcmb.2014-0476TR. Review. PubMed PMID: 25938935; PubMed Central PMCID: PMC4566071.

Saleh A, López-Campos JL, Hartl S, Pozo-Rodríguez F, Roberts CM. The Effect of Incidental Consolidation on Management and Outcomes in COPD Exacerbations: Data from the European COPD Audit. PLoS One. 2015;10(7):e0134004. doi: 10.1371/journal.pone.0134004. eCollection 2015. PubMed PMID: 26214175; PubMed Central PMCID: PMC4516303.

Pagano T, DiFrancesco AG, Smith SB, George J, Wink G, Rahman I, Robinson RJ. Determination of Nicotine Content and Delivery in Disposable Electronic Cigarettes Available in the United States by Gas Chromatography-Mass Spectrometry. Nicotine Tob Res. 2016 May;18(5):700-7. doi: 10.1093/ntr/ntv120. Epub 2015 Jun 4. PubMed PMID: 26045251; PubMed Central PMCID: PMC5896806.

Sundar IK, Ahmad T, Yao H, Hwang JW, Gerloff J, Lawrence BP, Sellix MT, Rahman I. Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD. Sci Rep. 2015 Apr 29;4:9927. doi: 10.1038/srep09927. PubMed PMID: 25923474; PubMed Central PMCID: PMC4413879.

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Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, Rahman I. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB J. 2015 Jul;29(7):2912-29. doi: 10.1096/fj.14-268276. Epub 2015 Mar 19. PubMed PMID: 25792665; PubMed Central PMCID: PMC4478793.

Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One. 2015;10(2):e0116732. doi: 10.1371/journal.pone.0116732. eCollection 2015. PubMed PMID: 25658421; PubMed Central PMCID: PMC4319729.

Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I. Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols. Environ Pollut. 2015 Mar;198:100-7. doi: 10.1016/j.envpol.2014.12.033. Epub 2015 Jan 9. PubMed PMID: 25577651; PubMed Central PMCID: PMC4323666.

Jo C, Gundemir S, Pritchard S, Jin YN, Rahman I, Johnson GV. Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. Nat Commun. 2014 Mar 25;5:3496. doi: 10.1038/ncomms4496. PubMed PMID: 24667209; PubMed Central PMCID: PMC3990284.

Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L, Rahman I. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L816-28. doi: 10.1152/ajplung.00323.2013. Epub 2014 Mar 14. PubMed PMID: 24633890; PubMed Central PMCID: PMC4010647.

Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I. Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis. PLoS One. 2014;9(2):e87999. doi: 10.1371/journal.pone.0087999. eCollection 2014. PubMed PMID: 24520342; PubMed Central PMCID: PMC3919731.

Biswas S, Hwang JW, Kirkham PA, Rahman I. Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease. Curr Med Chem. 2013;20(12):1496-530. doi: 10.2174/0929867311320120004. Review. PubMed PMID: 22963552.

Sundar IK, Nevid MZ, Friedman AE, Rahman I. Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer. J Proteome Res. 2014 Feb 7;13(2):982-96. doi: 10.1021/pr400998n. Epub 2013 Dec 13. PubMed PMID: 24283195; PubMed Central PMCID: PMC3975679.

Gilels F, Paquette ST, Zhang J, Rahman I, White PM. Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice. J Neurosci. 2013 Nov 20;33(47):18409-24. doi: 10.1523/JNEUROSCI.2529-13.2013. PubMed PMID: 24259566; PubMed Central PMCID: PMC6618809.

Yao H, Sundar IK, Gorbunova V, Rahman I. P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence. PLoS One. 2013;8(11):e80007. doi: 10.1371/journal.pone.0080007. eCollection 2013. PubMed PMID: 24244594; PubMed Central PMCID: PMC3823706.

Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest. 2013 Dec;123(12):5212-30. doi: 10.1172/JCI69636. Epub 2013 Nov 8. PubMed PMID: 24200693; PubMed Central PMCID: PMC3859407.

Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, Rahman I. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 1;305(9):L615-24. doi: 10.1152/ajplung.00249.2012. Epub 2013 Sep 13. PubMed PMID: 24039251; PubMed Central PMCID: PMC3840276.

Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. FASEB J. 2014 Jan;28(1):176-94. doi: 10.1096/fj.13-232629. Epub 2013 Sep 11. PubMed PMID: 24025728; PubMed Central PMCID: PMC3868829.

Hwang JW, Yao H, Caito S, Sundar IK, Rahman I. Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med. 2013 Aug;61:95-110. doi: 10.1016/j.freeradbiomed.2013.03.015. Epub 2013 Mar 27. Review. PubMed PMID: 23542362; PubMed Central PMCID: PMC3762912.

Sundar IK, Yao H, Rahman I. Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal. 2013 May 20;18(15):1956-71. doi: 10.1089/ars.2012.4863. Epub 2012 Nov 6. Review. PubMed PMID: 22978694; PubMed Central PMCID: PMC3624634.

Agarwal AR, Zhao L, Sancheti H, Sundar IK, Rahman I, Cadenas E. Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2012 Nov 15;303(10):L889-98. doi: 10.1152/ajplung.00219.2012. Epub 2012 Oct 12. PubMed PMID: 23064950.

Yao H, Rahman I. Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 1;303(7):L557-66. doi: 10.1152/ajplung.00175.2012. Epub 2012 Jul 27. Review. PubMed PMID: 22842217; PubMed Central PMCID: PMC3469586.

Basic VT, Tadele E, Elmabsout AA, Yao H, Rahman I, Sirsjö A, Abdel-Halim SM. Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L519-27. doi: 10.1152/ajplung.00007.2012. Epub 2012 Jul 27. PubMed PMID: 22842216; PubMed Central PMCID: PMC3468481.

Yao H, Rahman I. Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol. 2012 Nov 15;84(10):1332-9. doi: 10.1016/j.bcp.2012.06.031. Epub 2012 Jul 14. Review. PubMed PMID: 22796566; PubMed Central PMCID: PMC3482299.

Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest. 2012 Jun;122(6):2032-45. doi: 10.1172/JCI60132. Epub 2012 May 1. PubMed PMID: 22546858; PubMed Central PMCID: PMC3366403.

Rahman I, Kinnula VL. Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease. Expert Rev Clin Pharmacol. 2012 May;5(3):293-309. doi: 10.1586/ecp.12.16. Review. PubMed PMID: 22697592; PubMed Central PMCID: PMC3376391.

Klionsky DJ,. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496. PubMed PMID: 22966490; PubMed Central PMCID: PMC3404883.

Rahman I, MacNee W. Antioxidant pharmacological therapies for COPD. Curr Opin Pharmacol. 2012 Jun;12(3):256-65. doi: 10.1016/j.coph.2012.01.015. Epub 2012 Feb 18. Review. PubMed PMID: 22349417; PubMed Central PMCID: PMC3768007.

Sundar IK, Chung S, Hwang JW, Lapek JD Jr, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes. PLoS One. 2012;7(2):e31378. doi: 10.1371/journal.pone.0031378. Epub 2012 Feb 1. PubMed PMID: 22312446; PubMed Central PMCID: PMC3270039.

Mortaz E, Masjedi MR, Rahman I. Outcome of Smoking Cessation on Airway Remodeling and Pulmonary Inflammation in COPD Patients. Tanaffos. 2011;10(3):7-11. Review. PubMed PMID: 25191369; PubMed Central PMCID: PMC4153156.

Rahman I, Kinnula VL, Gorbunova V, Yao H. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med. 2012 May;54 Suppl(Suppl):S20-8. doi: 10.1016/j.ypmed.2011.11.014. Epub 2011 Dec 8. Review. PubMed PMID: 22178470; PubMed Central PMCID: PMC3311735.

Yang SR, Rahman I, Trosko JE, Kang KS. Oxidative stress-induced biomarkers for stem cell-based chemical screening. Prev Med. 2012 May;54 Suppl:S42-9. doi: 10.1016/j.ypmed.2011.11.013. Epub 2011 Dec 8. Review. PubMed PMID: 22197760.

Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochim Biophys Acta. 2012 May;1822(5):714-28. doi: 10.1016/j.bbadis.2011.11.004. Epub 2011 Nov 9. Review. PubMed PMID: 22101076; PubMed Central PMCID: PMC3295924.

Sundar IK, Rahman I. Vitamin d and susceptibility of chronic lung diseases: role of epigenetics. Front Pharmacol. 2011;2:50. doi: 10.3389/fphar.2011.00050. eCollection 2011. PubMed PMID: 21941510; PubMed Central PMCID: PMC3171063.

Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I. NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs. PLoS One. 2011;6(8):e23488. doi: 10.1371/journal.pone.0023488. Epub 2011 Aug 24. PubMed PMID: 21887257; PubMed Central PMCID: PMC3160853.

Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente L, Rahman I, Brookes PS. SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1506-12. doi: 10.1152/ajpheart.00587.2011. Epub 2011 Aug 19. PubMed PMID: 21856913; PubMed Central PMCID: PMC3197366.

Sundar IK, Mullapudi N, Yao H, Spivack SD, Rahman I. Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics. Curr Opin Pulm Med. 2011 Jul;17(4):279-85. doi: 10.1097/MCP.0b013e3283477533. Review. PubMed PMID: 21537190; PubMed Central PMCID: PMC3730439.

Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I. FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol. 2011 Jul 15;187(2):987-98. doi: 10.4049/jimmunol.1001861. Epub 2011 Jun 20. PubMed PMID: 21690325; PubMed Central PMCID: PMC3131437.

Londhe VA, Sundar IK, Lopez B, Maisonet TM, Yu Y, Aghai ZH, Rahman I. Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung. Pediatr Res. 2011 May;69(5 Pt 1):371-7. doi: 10.1203/PDR.0b013e318211c917. PubMed PMID: 21270677; PubMed Central PMCID: PMC3092484.

Sundar IK, Hwang JW, Wu S, Sun J, Rahman I. Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation. Biochem Biophys Res Commun. 2011 Mar 4;406(1):127-33. doi: 10.1016/j.bbrc.2011.02.011. Epub 2011 Feb 12. PubMed PMID: 21300024; PubMed Central PMCID: PMC3049841.

Yao H, Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol. 2011 Jul 15;254(2):72-85. doi: 10.1016/j.taap.2009.10.022. Epub 2011 Feb 4. Review. PubMed PMID: 21296096; PubMed Central PMCID: PMC3107364.

Rahman I, Chung S. Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. J Nutrigenet Nutrigenomics. 2010;3(4-6):220-30. doi: 10.1159/000324358. Epub 2011 Apr 6. Review. PubMed PMID: 21474953; PubMed Central PMCID: PMC3085527.

Adenuga D, Caito S, Yao H, Sundar IK, Hwang JW, Chung S, Rahman I. Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction. Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):452-6. doi: 10.1016/j.bbrc.2010.11.054. Epub 2010 Nov 19. PubMed PMID: 21094147; PubMed Central PMCID: PMC3031165.

Singh S, Vrishni S, Singh BK, Rahman I, Kakkar P. Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases. Free Radic Res. 2010 Nov;44(11):1267-88. doi: 10.3109/10715762.2010.507670. Review. PubMed PMID: 20815789.

Sundar IK, Chung S, Hwang JW, Arunachalam G, Cook S, Yao H, Mazur W, Kinnula VL, Fisher AB, Rahman I. Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury. Exp Lung Res. 2010 Oct;36(8):451-62. doi: 10.3109/01902141003754128. PubMed PMID: 20939758; PubMed Central PMCID: PMC3062974.

Ishikawa N, Ohlmeier S, Salmenkivi K, Myllärniemi M, Rahman I, Mazur W, Kinnula VL. Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD. Respir Res. 2010 Sep 13;11(1):123. doi: 10.1186/1465-9921-11-123. PubMed PMID: 20836851; PubMed Central PMCID: PMC2949726.

Nadtochiy SM, Redman E, Rahman I, Brookes PS. Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res. 2011 Feb 15;89(3):643-9. doi: 10.1093/cvr/cvq287. Epub 2010 Sep 7. PubMed PMID: 20823277; PubMed Central PMCID: PMC3028968.

Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15571-6. doi: 10.1073/pnas.1007625107. Epub 2010 Aug 16. PubMed PMID: 20713693; PubMed Central PMCID: PMC2932580.

Edirisinghe I, Rahman I. Cigarette smoke-mediated oxidative stress, shear stress, and endothelial dysfunction: role of VEGFR2. Ann N Y Acad Sci. 2010 Aug;1203:66-72. doi: 10.1111/j.1749-6632.2010.05601.x. Review. PubMed PMID: 20716285.

Arunachalam G, Sundar IK, Hwang JW, Yao H, Rahman I. Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. J Inflamm (Lond). 2010 Jul 22;7:34. doi: 10.1186/1476-9255-7-34. PubMed PMID: 20663150; PubMed Central PMCID: PMC2918603.

Sundar IK, Caito S, Yao H, Rahman I. Oxidative stress, thiol redox signaling methods in epigenetics. Methods Enzymol. 2010;474:213-44. doi: 10.1016/S0076-6879(10)74013-1. Epub 2010 Jun 20. PubMed PMID: 20609913.

Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I. Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells. Antioxid Redox Signal. 2010 Jun 15;12(12):1355-69. doi: 10.1089/ars.2009.2874. PubMed PMID: 19929443; PubMed Central PMCID: PMC2864667.

Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I. Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys. 2010 Aug 15;500(2):203-9. doi: 10.1016/j.abb.2010.05.013. Epub 2010 May 20. PubMed PMID: 20493163; PubMed Central PMCID: PMC2904411.

Chung S, Sundar IK, Yao H, Ho YS, Rahman I. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L192-203. doi: 10.1152/ajplung.00426.2009. Epub 2010 May 14. PubMed PMID: 20472709; PubMed Central PMCID: PMC2928604.

Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I. Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys. 2010 Sep 1;501(1):79-90. doi: 10.1016/j.abb.2010.05.003. Epub 2010 May 5. Review. PubMed PMID: 20450879; PubMed Central PMCID: PMC2930135.

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Rahman I, Chung S. Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. World Rev Nutr Diet. 2010;101:84-94. doi: 10.1159/000314513. Epub 2010 Apr 30. Review. PubMed PMID: 20436255.

Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 2010 Sep;24(9):3145-59. doi: 10.1096/fj.09-151308. Epub 2010 Apr 12. PubMed PMID: 20385619; PubMed Central PMCID: PMC2923349.

Adenuga D, Rahman I. Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch Biochem Biophys. 2010 Jun 1;498(1):62-73. doi: 10.1016/j.abb.2010.04.002. Epub 2010 Apr 11. PubMed PMID: 20388487; PubMed Central PMCID: PMC2874641.

Marwick JA, Edirisinghe I, Arunachalam G, Stevenson CS, Macnee W, Kirkham PA, Rahman I. Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs. J Inflamm (Lond). 2010 Feb 13;7(1):11. doi: 10.1186/1476-9255-7-11. PubMed PMID: 20205917; PubMed Central PMCID: PMC2831890.

Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun. 2010 Feb 26;393(1):66-72. doi: 10.1016/j.bbrc.2010.01.080. Epub 2010 Jan 25. PubMed PMID: 20102704; PubMed Central PMCID: PMC2830376.

Rajendrasozhan S, Hwang JW, Yao H, Kishore N, Rahman I. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther. 2010 Jun;23(3):172-81. doi: 10.1016/j.pupt.2010.01.002. Epub 2010 Jan 18. PubMed PMID: 20080200; PubMed Central PMCID: PMC2850968.

Vibhuti A, Arif E, Mishra A, Deepak D, Singh B, Rahman I, Mohammad G, Pasha MA. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Clin Chim Acta. 2010 Apr 2;411(7-8):474-80. doi: 10.1016/j.cca.2009.12.018. Epub 2010 Jan 18. PubMed PMID: 20080081.

Caito S, Hwang JW, Chung S, Yao H, Sundar IK, Rahman I. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity. Biochem Biophys Res Commun. 2010 Feb 12;392(3):264-70. doi: 10.1016/j.bbrc.2009.12.161. Epub 2010 Jan 10. PubMed PMID: 20060806; PubMed Central PMCID: PMC2824049.

Bancos S, Baglole CJ, Rahman I, Phipps RP. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. Cell Immunol. 2010;262(1):18-27. doi: 10.1016/j.cellimm.2009.12.003. Epub 2009 Dec 16. PubMed PMID: 20064636; PubMed Central PMCID: PMC3117258.

Yao H, Hwang JW, Moscat J, Diaz-Meco MT, Leitges M, Kishore N, Li X, Rahman I. Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. J Biol Chem. 2010 Feb 19;285(8):5405-16. doi: 10.1074/jbc.M109.041418. Epub 2009 Dec 11. PubMed PMID: 20007975; PubMed Central PMCID: PMC2820769.

Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I. Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L197-209. doi: 10.1152/ajplung.00265.2009. Epub 2009 Dec 4. PubMed PMID: 19965984; PubMed Central PMCID: PMC2822556.

Zakkar M, Van der Heiden K, Luong le A, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC, Evans PC. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1851-7. doi: 10.1161/ATVBAHA.109.193375. Epub 2009 Sep 3. PubMed PMID: 19729611.

Rajendrasozhan S, Yao H, Rahman I. Current perspectives on role of chromatin modifications and deacetylases in lung inflammation in COPD. COPD. 2009 Aug;6(4):291-7. doi: 10.1080/15412550903049132. Review. PubMed PMID: 19811389; PubMed Central PMCID: PMC2760053.

Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol. 2009 Aug;9(4):375-83. doi: 10.1016/j.coph.2009.06.009. Epub 2009 Jul 15. Review. PubMed PMID: 19615942; PubMed Central PMCID: PMC2730975.

Sarir H, Mortaz E, Karimi K, Kraneveld AD, Rahman I, Caldenhoven E, Nijkamp FP, Folkerts G. Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages. J Inflamm (Lond). 2009 May 1;6:12. doi: 10.1186/1476-9255-6-12. PubMed PMID: 19409098; PubMed Central PMCID: PMC2683828.

Yao H, de Boer WI, Rahman I. Targeting lung inflammation: novel therapies for the treatment of COPD. Curr Respir Med Rev. 2008;4(1):57-68. doi: 10.2174/157339808783497873. PubMed PMID: 19672474; PubMed Central PMCID: PMC2723817.

Louhelainen N, Myllärniemi M, Rahman I, Kinnula VL. Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: current and future perspectives. Int J Chron Obstruct Pulmon Dis. 2008;3(4):585-603. doi: 10.2147/copd.s3671. Review. PubMed PMID: 19281076; PubMed Central PMCID: PMC2650600.

Rahman I. Antioxidant therapeutic advances in COPD. Ther Adv Respir Dis. 2008 Dec;2(6):351-74. doi: 10.1177/1753465808098224. Review. PubMed PMID: 19124382; PubMed Central PMCID: PMC2744584.

Adenuga D, Yao H, March TH, Seagrave J, Rahman I. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol. 2009 Apr;40(4):464-73. doi: 10.1165/rcmb.2008-0255OC. Epub 2008 Oct 16. PubMed PMID: 18927347; PubMed Central PMCID: PMC2660563.

Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 2008 Sep;52(9):987-94. doi: 10.1002/mnfr.200700259. Review. PubMed PMID: 18327875.

Biswas SK, Rahman I. Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol Aspects Med. 2009 Feb-Apr;30(1-2):60-76. doi: 10.1016/j.mam.2008.07.001. Epub 2008 Aug 8. Review. PubMed PMID: 18760298; PubMed Central PMCID: PMC2699458.

Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ Jr, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. Am J Respir Cell Mol Biol. 2009 Feb;40(2):147-58. doi: 10.1165/rcmb.2008-0207OC. Epub 2008 Aug 7. PubMed PMID: 18688039; PubMed Central PMCID: PMC2633139.

Rahman I. Dietary polyphenols mediated regulation of oxidative stress and chromatin remodeling in inflammation. Nutr Rev. 2008 Aug;66 Suppl 1(Suppl 1):S42-5. doi: 10.1111/j.1753-4887.2008.00067.x. Review. PubMed PMID: 18673489; PubMed Central PMCID: PMC2556856.

Debret R, Brassart-Pasco S, Lorin J, Martoriati A, Deshorgue A, Maquart FX, Hornebeck W, Rahman I, Antonicelli F. Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation. Biochim Biophys Acta. 2008 Oct;1783(10):1718-27. doi: 10.1016/j.bbamcr.2008.06.001. Epub 2008 Jun 13. PubMed PMID: 18598724.

Meja KK, Rajendrasozhan S, Adenuga D, Biswas SK, Sundar IK, Spooner G, Marwick JA, Chakravarty P, Fletcher D, Whittaker P, Megson IL, Kirkham PA, Rahman I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol. 2008 Sep;39(3):312-23. doi: 10.1165/rcmb.2008-0012OC. Epub 2008 Apr 17. PubMed PMID: 18421014; PubMed Central PMCID: PMC2542449.

Yao H, Edirisinghe I, Yang SR, Rajendrasozhan S, Kode A, Caito S, Adenuga D, Rahman I. Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. Am J Pathol. 2008 May;172(5):1222-37. doi: 10.2353/ajpath.2008.070765. Epub 2008 Apr 10. PubMed PMID: 18403597; PubMed Central PMCID: PMC2329832.

Rajendrasozhan S, Yang SR, Edirisinghe I, Yao H, Adenuga D, Rahman I. Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD. Antioxid Redox Signal. 2008 Apr;10(4):799-811. doi: 10.1089/ars.2007.1938. Review. PubMed PMID: 18220485; PubMed Central PMCID: PMC2758554.

Yao H, Edirisinghe I, Rajendrasozhan S, Yang SR, Caito S, Adenuga D, Rahman I. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1174-86. doi: 10.1152/ajplung.00439.2007. Epub 2008 Mar 28. PubMed PMID: 18375740.

Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 2008 Jul;22(7):2297-310. doi: 10.1096/fj.07-099481. Epub 2008 Feb 8. PubMed PMID: 18263699; PubMed Central PMCID: PMC4708085.

Caito S, Yang SR, Kode A, Edirisinghe I, Rajendrasozhan S, Phipps RP, Rahman I. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. Antioxid Redox Signal. 2008 Feb;10(2):253-60. doi: 10.1089/ars.2007.1889. PubMed PMID: 17970647.

Yao H, Yang SR, Edirisinghe I, Rajendrasozhan S, Caito S, Adenuga D, O’Reilly MA, Rahman I. Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice. Am J Respir Cell Mol Biol. 2008 Jul;39(1):7-18. doi: 10.1165/rcmb.2007-0342OC. Epub 2008 Jan 31. PubMed PMID: 18239191; PubMed Central PMCID: PMC2440259.

Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I. IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. Am J Respir Cell Mol Biol. 2008 Jun;38(6):689-98. doi: 10.1165/rcmb.2007-0379OC. Epub 2008 Jan 31. PubMed PMID: 18239189; PubMed Central PMCID: PMC2396248.

Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008 Apr 15;177(8):861-70. doi: 10.1164/rccm.200708-1269OC. Epub 2008 Jan 3. PubMed PMID: 18174544; PubMed Central PMCID: PMC2292827.

de Boer WI, Yao H, Rahman I. Future therapeutic treatment of COPD: struggle between oxidants and cytokines. Int J Chron Obstruct Pulmon Dis. 2007;2(3):205-28. Review. PubMed PMID: 18229560; PubMed Central PMCID: PMC2695202.

Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L478-88. doi: 10.1152/ajplung.00361.2007. Epub 2007 Dec 27. PubMed PMID: 18162601.

Yao H, Yang SR, Kode A, Rajendrasozhan S, Caito S, Adenuga D, Henry R, Edirisinghe I, Rahman I. Redox regulation of lung inflammation: role of NADPH oxidase and NF-kappaB signalling. Biochem Soc Trans. 2007 Nov;35(Pt 5):1151-5. doi: 10.1042/BST0351151. Review. PubMed PMID: 17956299.

Aghai ZH, Kode A, Saslow JG, Nakhla T, Farhath S, Stahl GE, Eydelman R, Strande L, Leone P, Rahman I. Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants. Pediatr Res. 2007 Oct;62(4):483-8. doi: 10.1203/PDR.0b013e318142582d. PubMed PMID: 17667842.

Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, Butler K. Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation. Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1183-93. doi: 10.1152/ajplung.00105.2007. Epub 2007 Aug 24. PubMed PMID: 17720875.

Ryan EP, Bushnell TP, Friedman AE, Rahman I, Phipps RP. Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. Cancer Immunol Immunother. 2008 Mar;57(3):347-58. doi: 10.1007/s00262-007-0374-4. Epub 2007 Aug 1. PubMed PMID: 17668203; PubMed Central PMCID: PMC11031111.

Rahman I. Antioxidant therapies in COPD. Int J Chron Obstruct Pulmon Dis. 2006;1(1):15-29. doi: 10.2147/copd.2006.1.1.15. Review. PubMed PMID: 18046899; PubMed Central PMCID: PMC2706605.

Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc. 2006;1(6):3159-65. doi: 10.1038/nprot.2006.378. PubMed PMID: 17406579.

Kode A, Yang SR, Rahman I. Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res. 2006 Oct 24;7(1):132. doi: 10.1186/1465-9921-7-132. PubMed PMID: 17062156; PubMed Central PMCID: PMC1634855.

Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L567-76. doi: 10.1152/ajplung.00308.2006. Epub 2006 Oct 13. PubMed PMID: 17041012.

Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol. 2006 Nov 30;72(11):1439-52. doi: 10.1016/j.bcp.2006.07.004. Epub 2006 Aug 21. Review. PubMed PMID: 16920072.

Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J. 2006 Jul;28(1):219-42. doi: 10.1183/09031936.06.00053805. Review. PubMed PMID: 16816350.

Rahman I, Kilty I. Antioxidant therapeutic targets in COPD. Curr Drug Targets. 2006 Jun;7(6):707-20. doi: 10.2174/138945006777435254. Review. PubMed PMID: 16787173.

Aghai ZH, Kumar S, Farhath S, Kumar MA, Saslow J, Nakhla T, Eydelman R, Strande L, Stahl G, Hewitt C, Nesin M, Rahman I. Dexamethasone suppresses expression of Nuclear Factor-kappaB in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress. Pediatr Res. 2006 Jun;59(6):811-5. doi: 10.1203/01.pdr.0000219120.92049.b3. Epub 2006 Apr 26. PubMed PMID: 16641216.

Rahman I, Yang SR, Biswas SK. Current concepts of redox signaling in the lungs. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):681-9. doi: 10.1089/ars.2006.8.681. Review. PubMed PMID: 16677111.

Rahman I, Biswas SK, Kode A. Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol. 2006 Mar 8;533(1-3):222-39. doi: 10.1016/j.ejphar.2005.12.087. Epub 2006 Feb 28. Review. PubMed PMID: 16500642.

Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L46-57. doi: 10.1152/ajplung.00241.2005. Epub 2006 Feb 10. PubMed PMID: 16473865.

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Kirkham P, Rahman I. Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther. 2006 Aug;111(2):476-94. doi: 10.1016/j.pharmthera.2005.10.015. Epub 2006 Feb 3. Review. PubMed PMID: 16458359.

Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L19-29. doi: 10.1152/ajplung.00306.2005. Epub 2006 Jan 27. PubMed PMID: 16443644.

Rahman I. The role of oxidative stress in the pathogenesis of COPD: implications for therapy. Treat Respir Med. 2005;4(3):175-200. doi: 10.2165/00151829-200504030-00003. Review. PubMed PMID: 15987234.

Rahman I. Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms. Cell Biochem Biophys. 2005;43(1):167-88. doi: 10.1385/CBB:43:1:167. Review. PubMed PMID: 16043892.

Marwick JA, Stevenson CS, Giddings J, MacNee W, Butler K, Rahman I, Kirkham PA. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L897-908. doi: 10.1152/ajplung.00116.2005. Epub 2005 Dec 16. PubMed PMID: 16361360.

Biswas S, Chida AS, Rahman I. Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol. 2006 Feb 28;71(5):551-64. doi: 10.1016/j.bcp.2005.10.044. Epub 2005 Dec 6. PubMed PMID: 16337153.

Luppi F, Aarbiou J, van Wetering S, Rahman I, de Boer WI, Rabe KF, Hiemstra PS. Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione. Respir Res. 2005 Nov 25;6(1):140. doi: 10.1186/1465-9921-6-140. PubMed PMID: 16309548; PubMed Central PMCID: PMC1315328.

Bhattacharya K, Dopp E, Kakkar P, Jaffery FN, Schiffmann D, Jaurand MC, Rahman I, Rahman Q. Biomarkers in risk assessment of asbestos exposure. Mutat Res. 2005 Nov 11;579(1-2):6-21. doi: 10.1016/j.mrfmmm.2005.02.022. Epub 2005 Aug 19. Review. PubMed PMID: 16112146.

Rahman I. Regulation of glutathione in inflammation and chronic lung diseases. Mutat Res. 2005 Nov 11;579(1-2):58-80. doi: 10.1016/j.mrfmmm.2005.02.025. Epub 2005 Jul 27. Review. PubMed PMID: 16054171.

Rahman I, Biswas SK, Jimenez LA, Torres M, Forman HJ. Glutathione, stress responses, and redox signaling in lung inflammation. Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):42-59. doi: 10.1089/ars.2005.7.42. Review. PubMed PMID: 15650395.

Rahman I. Redox signaling in the lungs. Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):1-5. doi: 10.1089/ars.2005.7.1. PubMed PMID: 15650390.

Rahman I, Biswas SK. Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues. Redox Rep. 2004;9(3):125-43. doi: 10.1179/135100004225005219. Review. PubMed PMID: 15327743.

Echazarreta AL, Rahman I, Peinado V, Barberà JA, Roca J, MacNee W, Rodríguez-Roisin R. Lack of systemic oxidative stress during PAF challenge in mild asthma. Respir Med. 2005 May;99(5):519-23. doi: 10.1016/j.rmed.2004.10.013. Epub 2004 Nov 21. PubMed PMID: 15823446.

Rahman I, Marwick J, Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem Pharmacol. 2004 Sep 15;68(6):1255-67. doi: 10.1016/j.bcp.2004.05.042. Review. PubMed PMID: 15313424.

Lim SY, Jang JH, Na HK, Lu SC, Rahman I, Surh YJ. 15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. J Biol Chem. 2004 Oct 29;279(44):46263-70. doi: 10.1074/jbc.M406555200. Epub 2004 Aug 19. PubMed PMID: 15319433.

Kirkham PA, Spooner G, Rahman I, Rossi AG. Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products. Biochem Biophys Res Commun. 2004 May 21;318(1):32-7. doi: 10.1016/j.bbrc.2004.04.003. PubMed PMID: 15110749.

Rahman I. Reproducibility of oxidative stress biomarkers in breath condensate: are they reliable?. Eur Respir J. 2004 Feb;23(2):183-4. doi: 10.1183/09031936.04.00131604. PubMed PMID: 14979486.

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Deiana M, Dessi MA, Ke B, Liang YF, Higa T, Gilmour PS, Jen LS, Rahman I, Aruoma OI. The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro. Biochem Biophys Res Commun. 2002 Sep 6;296(5):1148-51. doi: 10.1016/s0006-291x(02)02061-2. PubMed PMID: 12207893.

Kim HJ, Liu X, Wang H, Kohyama T, Kobayashi T, Wen FQ, Romberger DJ, Abe S, MacNee W, Rahman I, Rennard SI. Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L409-17. doi: 10.1152/ajplung.00059.2002. PubMed PMID: 12114203.

Rahman I, MacNee W. Oxidative stress and adaptive response of glutathione in bronchial epithelial cells. Clin Exp Allergy. 2002 Apr;32(4):486-8. doi: 10.1046/j.0954-7894.2002.01368.x. PubMed PMID: 11972591.

Mantle D, Patel VB, Why HJ, Ahmed S, Rahman I, MacNee W, Wassif WS, Richardson PJ, Preedy VR. Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension. Clin Chim Acta. 2000 Sep;299(1-2):1-10. doi: 10.1016/s0009-8981(00)00270-9. PubMed PMID: 10900288.

Miralles C, Busquets X, Santos C, Togores B, Hussain S, Rahman I, MacNee W, Agustí AG. Regulation of iNOS expression and glutathione levels in rat liver by oxygen tension. FEBS Lett. 2000 Jul 7;476(3):253-7. doi: 10.1016/s0014-5793(00)01748-8. PubMed PMID: 10913623.

Lapperre TS, Jimenez LA, Antonicelli F, Drost EM, Hiemstra PS, Stolk J, MacNee W, Rahman I. Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells. FEBS Lett. 1999 Jan 25;443(2):235-9. doi: 10.1016/s0014-5793(98)01723-2. PubMed PMID: 9989612.

Rahman I, MacNee W. Oxidant/antioxidant imbalance in smokers and chronic obstructive pulmonary disease. Thorax. 1996 Apr;51(4):348-50. doi: 10.1136/thx.51.4.348. PubMed PMID: 8733482; PubMed Central PMCID: PMC1090665.

Rahman I, Massaro GD, Massaro D. Exposure of rats to ozone: evidence of damage to heart and brain. Free Radic Biol Med. 1992;12(4):323-6. doi: 10.1016/0891-5849(92)90119-2. PubMed PMID: 1577334.

Rahman I, Massaro D. Endotoxin treatment protects rats against ozone-induced lung edema: with evidence for the role of manganese superoxide dismutase. Toxicol Appl Pharmacol. 1992 Mar;113(1):13-8. doi: 10.1016/0041-008x(92)90003-b. PubMed PMID: 1553746.

Rahman I, Clerch LB, Massaro D. Rat lung antioxidant enzyme induction by ozone. Am J Physiol. 1991 Jun;260(6 Pt 1):L412-8. doi: 10.1152/ajplung.1991.260.6.L412. PubMed PMID: 2058686.

Rahman I, Nath N. Membrane potential and activities of certain membrane-bound enzymes of polymorphonuclear leukocytes in essential hypertension. Indian J Biochem Biophys. 1988 Aug;25(4):326-30. PubMed PMID: 2977122.

Rahman I, Nath N. Glutathione & its redox system, superoxide anion & superoxide dismutases of polymorphonuclear leukocytes in essential hypertension. Indian J Med Res. 1988 Jul;88:64-70. PubMed PMID: 2846441.

Rahman I, Nath N. Polymorphonuclear leukocytic sialic acid in essential hypertension. Indian Heart J. 1985 Nov-Dec;37(6):370-2. PubMed PMID: 3836939.